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dc.contributor.authorRotunno, Men_US
dc.contributor.authorSun, Xen_US
dc.contributor.authorFigueroa, Jen_US
dc.contributor.authorSherman, MEen_US
dc.contributor.authorGarcia-Closas, Men_US
dc.contributor.authorMeltzer, Pen_US
dc.contributor.authorWilliams, Ten_US
dc.contributor.authorSchneider, SSen_US
dc.contributor.authorJerry, DJen_US
dc.contributor.authorYang, XRen_US
dc.contributor.authorTroester, MAen_US
dc.date.accessioned2018-08-03T13:10:52Z
dc.date.issued2014-07-08en_US
dc.identifier.citationBreast cancer research : BCR, 2014, 16 (4), pp. R74 - ?en_US
dc.identifier.issn1465-5411en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2260
dc.identifier.eissn1465-542Xen_US
dc.identifier.doi10.1186/bcr3689en_US
dc.description.abstractINTRODUCTION:Relationships of parity with breast cancer risk are complex. Parity is associated with decreased risk of postmenopausal hormone receptor-positive breast tumors, but may increase risk for basal-like breast cancers and early-onset tumors. Characterizing parity-related gene expression patterns in normal breast and breast tumor tissues may improve understanding of the biological mechanisms underlying this complex pattern of risk. METHODS:We developed a parity signature by analyzing microRNA microarray data from 130 reduction mammoplasty (RM) patients (54 nulliparous and 76 parous). This parity signature, together with published parity signatures, was evaluated in gene expression data from 150 paired tumors and adjacent benign breast tissues from the Polish Breast Cancer Study, both overall and by tumor estrogen receptor (ER) status. RESULTS:We identified 251 genes significantly upregulated by parity status in RM patients (parous versus nulliparous; false discovery rate = 0.008), including genes in immune, inflammation and wound response pathways. This parity signature was significantly enriched in normal and tumor tissues of parous breast cancer patients, specifically in ER-positive tumors. CONCLUSIONS:Our data corroborate epidemiologic data, suggesting that the etiology and pathogenesis of breast cancers vary by ER status, which may have implications for developing prevention strategies for these tumors.en_US
dc.formatElectronicen_US
dc.format.extentR74 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectHumansen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectReceptors, Estrogenen_US
dc.subjectCluster Analysisen_US
dc.subjectOdds Ratioen_US
dc.subjectRisk Factorsen_US
dc.subjectCase-Control Studiesen_US
dc.subjectGene Expression Profilingen_US
dc.subjectParityen_US
dc.subjectPregnancyen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectMiddle Ageden_US
dc.subjectFemaleen_US
dc.subjectYoung Adulten_US
dc.subjectTranscriptomeen_US
dc.titleParity-related molecular signatures and breast cancer subtypes by estrogen receptor status.en_US
dc.typeJournal Article
dcterms.dateAccepted2014-06-25en_US
rioxxterms.versionofrecord10.1186/bcr3689en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2014-07-08en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBreast cancer research : BCRen_US
pubs.issue4en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Epidemiology
pubs.publication-statusPublisheden_US
pubs.volume16en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular Epidemiologyen_US
dc.contributor.icrauthorGarcia-Closas, Montserraten_US


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