| dc.contributor.author | Wilkerson, PM | |
| dc.contributor.author | Reis-Filho, JS | |
| dc.date.accessioned | 2018-08-07T14:29:42Z | |
| dc.date.issued | 2013-04 | |
| dc.identifier | 4 | |
| dc.identifier.citation | GENES CHROMOSOMES & CANCER, 2013, 52 pp. 333 - 355 | |
| dc.identifier.issn | 1045-2257 | |
| dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2284 | |
| dc.identifier.eissn | 1098-2264 | |
| dc.identifier.doi | 10.1002/gcc.22037 | |
| dc.description.abstract | Amplification at 11q13-q14 is a common event in cancers from multiple anatomical sites. This complex amplicon has multiple cores and several genes have been put forward as potential drivers. In this review, based on the technical advancements of the last decade, which resulted in methods allowing for a deeper genomic and functional genomic characterization of amplicons and their drivers, we discuss the current definitions of amplicons and driver genes, the clinical and biological significance of the 11q13-q14 amplicon in distinct types of human cancer, its coamplification partners, and the roles of various genes located within the amplicon as potential drivers. Finally, we appraise the available data for novel therapies targeting genes mapping to this amplicon. (c) 2012 Wiley Periodicals, Inc. | |
| dc.format.extent | 333 - 355 | |
| dc.language | eng | |
| dc.language.iso | eng | |
| dc.publisher | WILEY | |
| dc.title | the 11q13-q14 amplicon: Clinicopathological correlations and potential drivers | |
| dc.type | Journal Article | |
| rioxxterms.versionofrecord | 10.1002/gcc.22037 | |
| rioxxterms.licenseref.startdate | 2013-04 | |
| rioxxterms.type | Journal Article/Review | |
| dc.relation.isPartOf | GENES CHROMOSOMES & CANCER | |
| pubs.notes | affiliation: Reis-Filho, JS (Reprint Author), Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA. Wilkerson, Paul M.; Reis-Filho, Jorge S., Inst Canc Res, Breakthrough Breast Canc Res Ctr, Mol Pathol Team, London SW3 6JB, England. Reis-Filho, Jorge S., Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA. keywords-plus: SQUAMOUS-CELL CARCINOMA; COMPARATIVE GENOMIC HYBRIDIZATION; HUMAN-BREAST-CANCER; CYCLIN D1 EXPRESSION; GROWTH-FACTOR RECEPTOR; IN-SITU HYBRIDIZATION; TISSUE MICROARRAY ANALYSIS; GENE AMPLIFICATION; POOR-PROGNOSIS; TAMOXIFEN-RESISTANCE research-areas: Oncology; Genetics & Heredity web-of-science-categories: Oncology; Genetics & Heredity author-email: [email protected] funding-acknowledgement: Breakthrough Breast Cancer, Wellcome Trust funding-text: Supported by Breakthrough Breast Cancer, Wellcome Trust Clinical Fellowship Grant. number-of-cited-references: 241 times-cited: 21 usage-count-last-180-days: 0 usage-count-since-2013: 9 journal-iso: Gene Chromosomes Cancer doc-delivery-number: 090LW unique-id: ISI:000314981600001 da: 2018-08-07 | |
| pubs.notes | Not known | |
| pubs.organisational-group | /ICR | |
| pubs.organisational-group | /ICR/Primary Group | |
| pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
| pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
| pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Pathology | |
| pubs.organisational-group | /ICR | |
| pubs.organisational-group | /ICR/Primary Group | |
| pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
| pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
| pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Pathology | |
| pubs.volume | 52 | |
| pubs.embargo.terms | Not known | |
| icr.researchteam | Molecular Pathology | en_US |
| dc.contributor.icrauthor | Reis-Filho, Jorge Sergio | en |
