Publications Repository

Publications Repository

View Item 
  •   Home
  • ICR Divisions
  • Closed Research Teams
  • View Item
  • Home
  • ICR Divisions
  • Closed Research Teams
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis

Thumbnail
Publication Date
2012-11-13
ICR Author
Cross, Joe
Author
Harel, I
Maezawa, Y
Avraham, R
Rinon, A
Ma, H-Y
Cross, JW
Leviatan, N
Hegesh, J
Roy, A
Jacob-Hirsch, J
Rechavi, G
Carvajal, J
Tole, S
Kioussi, C
Quaggin, S
Tzahor, E
Type
Journal Article
Metadata
Show full item record
Abstract
The search for developmental mechanisms driving vertebrate organogenesis has paved the way toward a deeper understanding of birth defects. During embryogenesis, parts of the heart and craniofacial muscles arise from pharyngeal mesoderm (PM) progenitors. Here, we reveal a hierarchical regulatory network of a set of transcription factors expressed in the PM that initiates heart and craniofacial organogenesis. Genetic perturbation of this network in mice resulted in heart and craniofacial muscle defects, revealing robust cross-regulation between its members. We identified Lhx2 as a previously undescribed player during cardiac and pharyngeal muscle development. Lhx2 and Tcf21 genetically interact with Tbx1, the major determinant in the etiology of DiGeorge/velo-cardio-facial/22q11.2 deletion syndrome. Furthermore, knockout of these genes in the mouse recapitulates specific cardiac features of this syndrome. We suggest that PM-derived cardiogenesis and myogenesis are network properties rather than properties specific to individual PM members. These findings shed new light on the developmental underpinnings of congenital defects.
URL
https://repository.icr.ac.uk/handle/internal/2286
Collections
  • Closed Research Teams
Version of record
10.1073/pnas.1208690109
Research team
Molecular Embryology
Language
English
License start date
2012-11-13
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 pp. 18839 - 18844
Publisher
NATL ACAD SCIENCES

Browse

All of ICR repositoryICR DivisionsIssue dateAuthorsTitlesSubjectsThis collectionIssue dateAuthorsTitlesSubjects

Statistics

Most popular itemsStatistics by countryMost popular authors
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.