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The rationale for targeting the LOX family in cancer

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Date
2012-08
ICR Author
Erler, Janine Terra
Cox, Thomas
Baker, Holly
Author
Barker, HE
Cox, TR
Erler, JT
Type
Journal Article
Metadata
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Abstract
The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of evidence implicating the tumour microenvironment as pivotal in all aspects of tumour initiation and progression. Members of the lysyl oxidase (LOX) family of proteins are secreted by tumours and are the subject of much effort to understand their roles in cancer. In this Review we discuss the roles of members of this family in the remodelling of the tumour microenvironment and their paradoxical roles in tumorigenesis and metastasis. We also discuss how targeting this family of proteins might lead to a new avenue of cancer therapeutics.
URI
https://repository.icr.ac.uk/handle/internal/2297
DOI
https://doi.org/10.1038/nrc3319
Collections
  • Other ICR Research
Language
eng
License start date
2012-08
Citation
NATURE REVIEWS CANCER, 2012, 12 pp. 540 - 552
Publisher
NATURE PUBLISHING GROUP

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