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dc.contributor.authorNg, CKY
dc.contributor.authorPemberton, HN
dc.contributor.authorReis-Filho, JS
dc.date.accessioned2018-08-08T09:55:02Z
dc.date.issued2012-08
dc.identifier8
dc.identifier.citationEXPERT REVIEW OF ANTICANCER THERAPY, 2012, 12 pp. 1021 - 1032
dc.identifier.issn1473-7140
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2299
dc.identifier.doi10.1586/ERA.12.85
dc.description.abstractThere is burgeoning evidence to suggest that tumor evolution follows the laws of Darwinian evolution, whereby individual tumor cell clones harbor private genetic aberrations in addition to the founder mutations, and that these distinct populations of cancer cells interact in competitive and mutualistic manners. The combined effect of genetic and epigenetic instability, and differential selective pressures according to the microenvironment and therapeutic interventions, create many different evolutionary routes such that intratumor heterogeneity is inevitable. Numerous cytogenetic, comparative genomic hybridization and, more recently, massively parallel sequencing studies have generated indisputable evidence of this phenomenon. The impact of intratumor heterogeneity on response and resistance to therapy is beginning to be understood; this information may prove crucial for the potentials of personalized medicine to be realized. In this review, the evidence of intratumor heterogeneity in breast cancer, its potential causes and implications for the clinical management of breast cancer patients are discussed.
dc.format.extent1021 - 1032
dc.languageeng
dc.language.isoeng
dc.publisherEXPERT REVIEWS
dc.titleBreast cancer intratumor genetic heterogeneity: causes and implications
dc.typeJournal Article
rioxxterms.versionofrecord10.1586/ERA.12.85
rioxxterms.licenseref.startdate2012-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfEXPERT REVIEW OF ANTICANCER THERAPY
pubs.notesaffiliation: Reis, JS (Reprint Author), Inst Canc Res, Breakthrough Breast Canc Res Ctr, Mol Pathol Team, London SW3 6JB, England. Ng, Charlotte K. Y.; Pemberton, Helen N.; Reis-Filho, Jorge S., Inst Canc Res, Breakthrough Breast Canc Res Ctr, Mol Pathol Team, London SW3 6JB, England. keywords: breast cancer; clonal evolution; drug resistance; genomic instability; intratumor heterogeneity keywords-plus: ISLAND METHYLATOR PHENOTYPE; CHRONIC MYELOID-LEUKEMIA; KINASE DOMAIN MUTATIONS; LYMPH-NODE METASTASES; OVARIAN CARCINOMAS; COLORECTAL-CANCER; CLONAL EVOLUTION; TUMOR-CELLS; IN-SITU; MICROSATELLITE INSTABILITY research-areas: Oncology web-of-science-categories: Oncology author-email: [email protected] orcid-numbers: Ng, Charlotte K Y/0000-0002-6100-0026 funding-acknowledgement: Breakthrough Breast Cancer; NHS funding-text: CKY Ng, HN Pemberton and JS Reis-Filho are funded by Breakthrough Breast Cancer. The authors also acknowledge NHS funding for the National Institute of Health Research Biomedical Research Centre. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. number-of-cited-references: 108 times-cited: 42 usage-count-last-180-days: 0 usage-count-since-2013: 14 journal-iso: Expert Rev. Anticancer Ther doc-delivery-number: 031PZ unique-id: ISI:000310655700010 da: 2018-08-08
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.volume12en_US
pubs.embargo.termsNot known
icr.researchteamGene Functionen_US
dc.contributor.icrauthorReis-Filho, Jorge Sergioen
dc.contributor.icrauthorPemberton, Helenen


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