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Predisposition alleles for testicular germ cell tumour

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Date
2010-06
ICR Author
Rapley, Elizabeth
Author
Rapley, EA
Nathanson, KL
Type
Journal Article
Metadata
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Abstract
For some time, it has been known that there is a substantial genetic component to testicular germ cell tumour susceptibility, supported by several pieces of evidence, including the significantly increased familial risk and differential risk among races. However, despite extensive linkage searches on available families, no high penetrance genes have been identified. Recently genome-wide association studies have revealed three candidate loci, which confer up to a fourfold risk of developing TGCT. The genome-wide association studies for this cancer are noteworthy, because of the high effect sizes demonstrated at each loci and the biological plausibility of the genes at or near the associated SNPs, particularly KITLG.
URI
https://repository.icr.ac.uk/handle/internal/2369
DOI
https://doi.org/10.1016/j.gde.2010.02.006
Collections
  • Breast Cancer Research
  • Genetics and Epidemiology
Research team
Genetic Susceptibility
Language
eng
License start date
2010-06
Citation
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2010, 20 pp. 225 - 230
Publisher
CURRENT BIOLOGY LTD

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