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dc.contributor.authorDekker, Cen_US
dc.date.accessioned2018-08-24T11:09:52Z
dc.date.issued2010-02-05en_US
dc.identifier3en_US
dc.identifier.citationFEBS LETTERS, 2010, 584 pp. 477 - 481en_US
dc.identifier.issn0014-5793en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2386
dc.identifier.doi10.1016/j.febslet.2009.11.088en_US
dc.description.abstractThe just-in-time hypothesis relates to the assembly of large multi-protein complexes and their regulation of activation in the cell. Here I postulate that chaperonins may contribute to the timely assembly and activation of such complexes. For the case of anaphase promoting complex/cyclosome(Cdc20) assembly by the eukaryotic chaperonin chaperonin containing Tcp1 it is shown that just-in-time synthesis and chaperone-assisted folding can synergise to generate a highly regulated assembly process of a protein complex that is vital for cell cycle progression. Once dependency has been established transcriptional regulation and chaperonin-dependency may have co-evolved to safeguard the timely activation of important multi-protein complexes. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.en_US
dc.format.extent477 - 481en_US
dc.languageEnglishen_US
dc.language.isoEnglishen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.titleOn the role of the chaperonin CCT in the just-in-time assembly process of APC/C-Cdc20en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/j.febslet.2009.11.088en_US
rioxxterms.licenseref.startdate2010-02-05en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfFEBS LETTERSen_US
pubs.notesaffiliation: Dekker, C (Reprint Author), Inst Canc Res, 237 Fulham Rd, London SW3 6JB, England. Inst Canc Res, London SW3 6JB, England. keywords: Chaperonin; CCT; APC/C; Just-in-time-assembly keywords-plus: CYCLE-REGULATED GENES; CELL-CYCLE; SACCHAROMYCES-CEREVISIAE; YEAST; COMPLEX; IDENTIFICATION; TRANSCRIPTION; INTERACTOME; EVOLUTION; MACHINE research-areas: Biochemistry & Molecular Biology; Biophysics; Cell Biology web-of-science-categories: Biochemistry & Molecular Biology; Biophysics; Cell Biology author-email: cdekker@icr.ac.uk number-of-cited-references: 23 times-cited: 4 usage-count-last-180-days: 0 usage-count-since-2013: 0 journal-iso: FEBS Lett. doc-delivery-number: 547AZ unique-id: ISI:000273858600003 oa: gold_or_bronze da: 2018-08-23en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume584en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorDekker, Carienen_US


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