dc.contributor.author | Dekker, C | |
dc.date.accessioned | 2018-08-24T11:09:52Z | |
dc.date.issued | 2010-02-05 | |
dc.identifier | 3 | |
dc.identifier.citation | FEBS LETTERS, 2010, 584 pp. 477 - 481 | |
dc.identifier.issn | 0014-5793 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2386 | |
dc.identifier.doi | 10.1016/j.febslet.2009.11.088 | |
dc.description.abstract | The just-in-time hypothesis relates to the assembly of large multi-protein complexes and their regulation of activation in the cell. Here I postulate that chaperonins may contribute to the timely assembly and activation of such complexes. For the case of anaphase promoting complex/cyclosome(Cdc20) assembly by the eukaryotic chaperonin chaperonin containing Tcp1 it is shown that just-in-time synthesis and chaperone-assisted folding can synergise to generate a highly regulated assembly process of a protein complex that is vital for cell cycle progression. Once dependency has been established transcriptional regulation and chaperonin-dependency may have co-evolved to safeguard the timely activation of important multi-protein complexes. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | |
dc.format.extent | 477 - 481 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE BV | |
dc.title | On the role of the chaperonin CCT in the just-in-time assembly process of APC/C-Cdc20 | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1016/j.febslet.2009.11.088 | |
rioxxterms.licenseref.startdate | 2010-02-05 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | FEBS LETTERS | |
pubs.notes | affiliation: Dekker, C (Reprint Author), Inst Canc Res, 237 Fulham Rd, London SW3 6JB, England. Inst Canc Res, London SW3 6JB, England. keywords: Chaperonin; CCT; APC/C; Just-in-time-assembly keywords-plus: CYCLE-REGULATED GENES; CELL-CYCLE; SACCHAROMYCES-CEREVISIAE; YEAST; COMPLEX; IDENTIFICATION; TRANSCRIPTION; INTERACTOME; EVOLUTION; MACHINE research-areas: Biochemistry & Molecular Biology; Biophysics; Cell Biology web-of-science-categories: Biochemistry & Molecular Biology; Biophysics; Cell Biology author-email: [email protected] number-of-cited-references: 23 times-cited: 4 usage-count-last-180-days: 0 usage-count-since-2013: 0 journal-iso: FEBS Lett. doc-delivery-number: 547AZ unique-id: ISI:000273858600003 oa: gold_or_bronze da: 2018-08-23 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR | |
pubs.volume | 584 | |
pubs.embargo.terms | Not known | |
dc.contributor.icrauthor | Dekker, Carien | en |