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dc.contributor.authorFernandez, Aen_US
dc.contributor.authorBrada, Men_US
dc.contributor.authorZabuliene, Len_US
dc.contributor.authorKaravitaki, Nen_US
dc.contributor.authorWass, JAHen_US
dc.date.accessioned2018-08-29T08:38:35Z
dc.date.issued2009-09en_US
dc.identifier3en_US
dc.identifier.citationENDOCRINE-RELATED CANCER, 2009, 16 pp. 733 - 772en_US
dc.identifier.issn1351-0088en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2395
dc.identifier.eissn1479-6821en_US
dc.identifier.doi10.1677/ERC-08-0231en_US
dc.description.abstractThe hypothalamic-pituitary unit is a particularly radiosensitive region in the central nervous system. As a consequence, hypopituitarism commonly develops after radiation treatments for sellar and parasellar neoplasms, extrasellar brain tumours, head and neck tumours, and following whole body irradiation for systemic malignancies. Increasing tumour-related survival rates provide an expanding population at risk of developing hypopituitarism. In this population, long-term monitoring tailored to the individual risk profile is required to avoid the sequelae of untreated pituitary hormonal deficiencies and resultant decrease in the quality of life. This review analyses the pathogenesis, prevalence and consequences of radiation-induced hypopituitarism (RIH) in diverse subgroups at risk Also discussed is the impact of modern radiotherapy techniques in the prevalence of RIH, the spectrum of endocrine disorders and radiation-induced brain conditions that also occur in patients with RIH.en_US
dc.format.extent733 - 772en_US
dc.languageEnglishen_US
dc.language.isoEnglishen_US
dc.publisherBIOSCIENTIFICA LTDen_US
dc.titleRadiation-induced hypopituitarismen_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1677/ERC-08-0231en_US
rioxxterms.licenseref.startdate2009-09en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfENDOCRINE-RELATED CANCERen_US
pubs.notesaffiliation: Wass, JAH (Reprint Author), Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Dept Endocrinol, Old Rd, Oxford OX3 7LE, England. Fernandez, Alberto; Karavitaki, Niki; Wass, John A. H., Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Dept Endocrinol, Oxford OX3 7LE, England. Brada, Michael, Inst Canc Res, Surrey, England. Brada, Michael, Royal Marsden Natl Hlth Serv Fdn Trust, Surrey, England. Zabuliene, Lina, Vilnius State Univ, Fac Med, Dept Anat Histol & Anthropol, Vilnius, Lithuania. keywords-plus: GROWTH-HORMONE DEFICIENCY; TERM-FOLLOW-UP; GAMMA-KNIFE RADIOSURGERY; PITUITARY-ADRENAL AXIS; BONE-MINERAL DENSITY; ACUTE LYMPHOBLASTIC-LEUKEMIA; QUALITY-OF-LIFE; INSULIN-INDUCED HYPOGLYCEMIA; CHILDHOOD-CANCER SURVIVOR; DOSE METYRAPONE TEST research-areas: Oncology; Endocrinology & Metabolism web-of-science-categories: Oncology; Endocrinology & Metabolism orcid-numbers: KARAVITAKI, NIKI/0000-0002-4696-0643 number-of-cited-references: 295 times-cited: 42 usage-count-last-180-days: 1 usage-count-since-2013: 6 journal-iso: Endocr.-Relat. Cancer doc-delivery-number: 531ML unique-id: ISI:000272670300005 oa: gold_or_bronze da: 2018-08-24en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Clinical Academic Radiotherapy (Brada)
pubs.volume16en_US
pubs.embargo.termsNot knownen_US
icr.researchteamClinical Academic Radiotherapy (Brada)en_US
dc.contributor.icrauthorBrada, Michaelen_US


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