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Positive Selection of Tyrosine Loss in Metazoan Evolution

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Date
2009-09-25
ICR Author
Linding, Rune
Author
Tan, CSH
Pasculescu, A
Lim, WA
Pawson, T
Bader, GD
Linding, R
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Type
Journal Article
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Abstract
John Nash showed that within a complex system, individuals are best off if they make the best decision that they can, taking into account the decisions of the other individuals. Here, we investigate whether similar principles influence the evolution of signaling networks in multicellular animals. Specifically, by analyzing a set of metazoan species we observed a striking negative correlation of genomically encoded tyrosine content with biological complexity (as measured by the number of cell types in each organism). We discuss how this observed tyrosine loss correlates with the expansion of tyrosine kinases in the evolution of the metazoan lineage and how it may relate to the optimization of signaling systems in multicellular animals. We propose that this phenomenon illustrates genome-wide adaptive evolution to accommodate beneficial genetic perturbation.
URI
https://repository.icr.ac.uk/handle/internal/2397
DOI
https://doi.org/10.1126/science.1174301
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Language
eng
License start date
2009-09-25
Citation
SCIENCE, 2009, 325 pp. 1686 - 1688
Publisher
AMER ASSOC ADVANCEMENT SCIENCE

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