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Positive Selection of Tyrosine Loss in Metazoan Evolution

dc.contributor.authorTan, CSH
dc.contributor.authorPasculescu, A
dc.contributor.authorLim, WA
dc.contributor.authorPawson, T
dc.contributor.authorBader, GD
dc.contributor.authorLinding, R
dc.date.accessioned2018-08-29T08:38:50Z
dc.date.issued2009-09-25
dc.identifier5948
dc.identifier.citationSCIENCE, 2009, 325 pp. 1686 - 1688
dc.identifier.issn0036-8075
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2397
dc.identifier.doi10.1126/science.1174301
dc.description.abstractJohn Nash showed that within a complex system, individuals are best off if they make the best decision that they can, taking into account the decisions of the other individuals. Here, we investigate whether similar principles influence the evolution of signaling networks in multicellular animals. Specifically, by analyzing a set of metazoan species we observed a striking negative correlation of genomically encoded tyrosine content with biological complexity (as measured by the number of cell types in each organism). We discuss how this observed tyrosine loss correlates with the expansion of tyrosine kinases in the evolution of the metazoan lineage and how it may relate to the optimization of signaling systems in multicellular animals. We propose that this phenomenon illustrates genome-wide adaptive evolution to accommodate beneficial genetic perturbation.
dc.format.extent1686 - 1688
dc.languageeng
dc.language.isoeng
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE
dc.titlePositive Selection of Tyrosine Loss in Metazoan Evolution
dc.typeJournal Article
rioxxterms.versionofrecord10.1126/science.1174301
rioxxterms.licenseref.startdate2009-09-25
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfSCIENCE
pubs.notesaffiliation: Pawson, T (Reprint Author), Mt Sinai Hosp, Samuel Lunenfeld Res Inst, 600 Univ Ave, Toronto, ON M5G 1X5, Canada. Tan, Chris Soon Heng; Pasculescu, Adrian; Pawson, Tony; Bader, Gary D., Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada. Tan, Chris Soon Heng; Pawson, Tony; Bader, Gary D., Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada. Tan, Chris Soon Heng; Bader, Gary D., Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada. Lim, Wendell A., Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94158 USA. Lim, Wendell A., Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94158 USA. Linding, Rune, Inst Canc Res, Cellular & Mol Log Team, Sect Cell & Mol Biol, London SW3 6JB, England. keywords-plus: PHOSPHORYLATION NETWORKS; BIOLOGICAL COMPLEXITY; MONOSIGA-BREVICOLLIS; GENOME research-areas: Science & Technology - Other Topics web-of-science-categories: Multidisciplinary Sciences author-email: [email protected] [email protected] [email protected] researcherid-numbers: Bader, Gary/C-1176-2009 Pawson, Tony/E-4578-2013 Tan, Soon Heng/C-1177-2009 orcid-numbers: Bader, Gary/0000-0003-0185-8861 funding-acknowledgement: Genome Canada through the Ontario Genomics Institute and the Canadian Institutes of Health Research [MOP-84324] funding-text: We thank C. Jorgensen, J. Zhang, K. Colwill, T. J. Gibson, J. Jin, and K. Lindorff-Larsen for suggestions and fruitful discussions. This project was in part supported by Genome Canada through the Ontario Genomics Institute and the Canadian Institutes of Health Research (MOP-84324). C. S. H. T. conceived the project. C. S. H. T., W. A. L., G. D. B., T. P., and R. L. designed the experiments. C. S. H. T., R. L., and A. P. performed the experiments. C. S. H. T., G. D. B., W. A. L., T. P., and R. L. wrote the paper. R. L. managed the project. number-of-cited-references: 17 times-cited: 70 usage-count-last-180-days: 0 usage-count-since-2013: 14 journal-iso: Science doc-delivery-number: 498II unique-id: ISI:000270131800045 oa: green_accepted da: 2018-08-24
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.volume325
pubs.embargo.termsNot known
dc.contributor.icrauthorLinding, Runeen


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