Publications Repository

Publications Repository

View item 
  •   Home
  • ICR Divisions
  • Other ICR Research
  • View item
  • Home
  • ICR Divisions
  • Other ICR Research
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

NetworKIN: a resource for exploring cellular phosphorylation networks

Thumbnail
Date
2008-01
ICR Author
Linding, Rune
Author
Linding, R
Jensen, LJ
Pasculescu, A
Olhovsky, M
Colwill, K
Bork, P
Yaffe, MB
Pawson, T
Show allShow less
Type
Journal Article
Metadata
Show full item record
Abstract
Protein kinases control cellular responses by phosphorylating specific substrates. Recent proteome-wide mapping of protein phosphorylation sites by mass spectrometry has discovered thousands of in vivo sites. Systematically assigning all 518 human kinases to all these sites is a challenging problem. The NetworKIN database (http://networkin.info) integrates consensus substrate motifs with context modelling for improved prediction of cellular kinase-substrate relations. Based on the latest human phosphoproteome from the Phospho. ELM and PhosphoSite databases, the resource offers insight into phosphorylation-modulated interaction networks. Here, we describe how NetworKIN can be used for both global and targeted molecular studies. Via the web interface users can query the database of precomputed kinase-substrate relations or obtain predictions on novel phosphoproteins. The database currently contains a predicted phosphorylation network with 20 224 site-specific interactions involving 3978 phosphoproteins and 73 human kinases from 20 families.
URI
https://repository.icr.ac.uk/handle/internal/2425
DOI
https://doi.org/10.1093/nar/gkm902
Collections
  • Other ICR Research
Language
eng
License start date
2008-01
Citation
NUCLEIC ACIDS RESEARCH, 2008, 36 pp. D695 - D699
Publisher
OXFORD UNIV PRESS

Browse

All of ICR repositoryICR DivisionsBy issue dateAuthorsTitlesPublication TypesThis collectionBy issue dateAuthorsTitlesPublication Types
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.