Publications Repository

Publications Repository

View item 
  •   Home
  • ICR Divisions
  • Other ICR Research
  • View item
  • Home
  • ICR Divisions
  • Other ICR Research
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer

Thumbnail
Date
2008-04-22
ICR Author
Crook, Timothy
Syed, Nelofer
Author
Lim, SL
Smith, P
Syed, N
Coens, C
Wong, H
van der Burg, M
Szlosarek, P
Crook, T
Green, JA
Show allShow less
Type
Journal Article
Metadata
Show full item record
Abstract
The Fanconi gene family has a role in DNA repair and inactivation of FANCF has been proposed as a mechanism of sensitisation to platinum chemotherapy. This study sought to confirm this hypothesis in cell lines and a large series of ovarian cancer samples. Promoter methylation was assessed by methylation-sensitive polymerase chain reaction of FANCF in nine ovarian cancer cell lines and 74 ovarian cancer samples taken from patients entered on a trial of cisplatin-based chemotherapy. This study confirmed methylation-dependent silencing of FANCF in one out of nine ovarian cancer cell lines. Methylation of FANCF was demonstrated in 13.2% of 53 evaluable ovarian tumour samples. Progression-free survival gave an HR of 3.63 ( 95% CI: 1.54 - 8.54, P = 0.0016) in favour of the unmethylated cases. There was no association with overall survival. This study does not support methylation-dependent silencing of FANCF as a mechanism of sensitisation to platinum-based chemotherapy in ovarian cancer.
URI
https://repository.icr.ac.uk/handle/internal/2426
DOI
https://doi.org/10.1038/sj.bjc.6604325
Collections
  • Other ICR Research
Language
eng
License start date
2008-04-22
Citation
BRITISH JOURNAL OF CANCER, 2008, 98 pp. 1452 - 1456
Publisher
NATURE PUBLISHING GROUP

Browse

All of ICR repositoryICR DivisionsBy issue dateAuthorsTitlesPublication TypesThis collectionBy issue dateAuthorsTitlesPublication Types
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.