Network medicine
Date
2008-02-20ICR Author
Author
Pawson, T
Linding, R
Type
Journal Article
Metadata
Show full item recordAbstract
To more effectively target complex diseases like cancer, diabetes and schizophrenia, we may need to rethink our strategies for drug development and the selection of molecular targets for pharmacological treatments. Here, we discuss the potential use of protein signaling networks as the targets for new therapeutic intervention. We argue that by targeting the architecture of aberrant signaling networks associated with cancer and other diseases new therapeutic strategies can be implemented. Transforming medicine into a network driven endeavour will require quantitative measurements of cell signaling processes; we will describe how this may be performed and combined with new algorithms to predict the trajectories taken by a cellular system either in time or through disease states. We term this approach, network medicine.
Collections
Subject
Systems biology
Proteomics
Quantitative mass-spectrometry
Computational biology
Network medicine
Network biology
Language
eng
License start date
2008-02-20
Citation
FEBS Letters, 2008, 582 (8), pp. 1266 - 1270
Publisher
Wiley-Blackwell