dc.contributor.author | Dungarwalla, M | |
dc.contributor.author | Matutes, E | |
dc.contributor.author | Dearden, CE | |
dc.date.accessioned | 2018-08-30T13:39:51Z | |
dc.date.issued | 2008-06 | |
dc.identifier | 6 | |
dc.identifier.citation | EUROPEAN JOURNAL OF HAEMATOLOGY, 2008, 80 pp. 469 - 476 | |
dc.identifier.issn | 0902-4441 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2429 | |
dc.identifier.eissn | 1600-0609 | |
dc.identifier.doi | 10.1111/j.1600-0609.2008.01069.x | |
dc.description.abstract | Prolymphocytic leukaemias of B and T cell subtype are rare diseases. Despite recent advances in immunophenotyping and molecular cytogenetics, leading to a better understanding of the underlying cell biology of the prolymphocytic leukaemias, prognosis for these patients remains poor. Purine analogues and monoclonal antibodies have shown efficacy in B-cell prolymphocytic leukaemia although further studies are warranted. Monoclonal antibody therapy with alemtuzumab has significantly improved outcome in T-cell prolymphocytic leukaemia (T-PLL) but responses are still transient and further disease progression is inevitable. While allogeneic stem cell transplant is an attractive option, due to the older age group of T-PLL patients the morbidity and mortality associated with the procedure is significant. | |
dc.format.extent | 469 - 476 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY | |
dc.title | Prolymphocytic leukaemia of B- and T-cell subtype: a state-of-the-art paper | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1111/j.1600-0609.2008.01069.x | |
rioxxterms.licenseref.startdate | 2008-06 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | EUROPEAN JOURNAL OF HAEMATOLOGY | |
pubs.notes | affiliation: Dearden, CE (Reprint Author), Royal Marsden Hosp, Dept Haematooncol, Haematooncol Unit, Downs Rd, Sutton SM2 5PT, Surrey, England. Dungarwalla, M.; Matutes, E.; Dearden, C. E., Royal Marsden Hosp, Dept Haematooncol, Haematooncol Unit, Sutton SM2 5PT, Surrey, England. keywords: prolymphocytic leukaemia; cell biology; clinical features; management keywords-plus: CHRONIC LYMPHOCYTIC-LEUKEMIA; ATAXIA-TELANGIECTASIA; ATM GENE; MALIGNANCIES; CAMPATH-1H; CHEMOTHERAPY; EXPRESSION; CLASSIFICATION; TRANSLOCATIONS; ABNORMALITIES research-areas: Hematology web-of-science-categories: Hematology author-email: [email protected] number-of-cited-references: 49 times-cited: 37 usage-count-last-180-days: 0 usage-count-since-2013: 3 journal-iso: Eur. J. Haematol. doc-delivery-number: 298QF unique-id: ISI:000255701500002 oa: gold_or_bronze da: 2018-08-30 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers) | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers) | |
pubs.volume | 80 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Molecular Haematology (including Cytogenetics Group and Cell Markers) | en_US |
dc.contributor.icrauthor | Matutes, Estella | en |
dc.contributor.icrauthor | Dearden, Claire | en |