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dc.contributor.authorAntoniou, ACen_US
dc.contributor.authorCunningham, APen_US
dc.contributor.authorPeto, Jen_US
dc.contributor.authorEvans, DGen_US
dc.contributor.authorLalloo, Fen_US
dc.contributor.authorNarod, SAen_US
dc.contributor.authorRisch, HAen_US
dc.contributor.authorEyfjord, JEen_US
dc.contributor.authorHopper, JLen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorOlsson, Hen_US
dc.contributor.authorJohannsson, Oen_US
dc.contributor.authorBorg, Aen_US
dc.contributor.authorPassini, Ben_US
dc.contributor.authorRadice, Pen_US
dc.contributor.authorManoukian, Sen_US
dc.contributor.authorEccles, DMen_US
dc.contributor.authorTang, Nen_US
dc.contributor.authorOlah, Een_US
dc.contributor.authorAnton-Culver, Hen_US
dc.contributor.authorWarner, Een_US
dc.contributor.authorLubinski, Jen_US
dc.contributor.authorGronwald, Jen_US
dc.contributor.authorGorski, Ben_US
dc.contributor.authorTryggvadottir, Len_US
dc.contributor.authorSyrjakoski, Ken_US
dc.contributor.authorKallioniemi, O-Pen_US
dc.contributor.authorEerola, Hen_US
dc.contributor.authorNevanlinna, Hen_US
dc.contributor.authorPharoah, PDPen_US
dc.contributor.authorEaston, DFen_US
dc.identifier.citationBRITISH JOURNAL OF CANCER, 2008, 98 pp. 1457 - 1466en_US
dc.description.abstractMultiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes ( polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families ( 301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920 - 1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in userfriendly Web-based program( html).en_US
dc.format.extent1457 - 1466en_US
dc.titleThe BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensionsen_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
pubs.notesaffiliation: Antoniou, AC (Reprint Author), Univ Cambridge, Genet Epidemiol Unit, Canc Res UK, Strangeways Res Lab,Dept Publ Hlth & Primary Care, Worts Causeway, Cambridge CB1 8RN, England. Antoniou, A. C.; Cunningham, A. P.; Easton, D. F., Univ Cambridge, Genet Epidemiol Unit, Canc Res UK, Strangeways Res Lab,Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England. Peto, J., Inst Canc Res, Epidemiol Sect, Sutton, Surrey, England. Peto, J., London Sch Hyg & Trop Med, Epidemiol Sect, London WC1, England. Evans, D. G.; Lalloo, F., St Marys Hosp, Med Genet & Reg Genet Serv, Acad Unit, Manchester, Lancs, England. Narod, S. A., Univ Toronto, Ctr Res Womens Hlth, Toronto, ON, Canada. Risch, H. A., Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA. Eyfjord, J. E.; Tryggvadottir, L., Univ Iceland, Fac Med, Reykjavik, Iceland. Eyfjord, J. E.; Tryggvadottir, L., Iceland Canc Soc, Reykjavik, Iceland. Hopper, J. L., Univ Melbourne, Ctr Mol Environm Genet & Anal Epidemiol, Melbourne, Vic, Australia. Southey, M. C., Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Melbourne, Vic, Australia. Olsson, H.; Johannsson, O.; Borg, A., Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden. Passini, B.; Radice, P.; Manoukian, S., Fondazione IRCCS Ist Nazl Tumori, Milan, Italy. Radice, P., IFOM Fondazione Ist FIRC Oncol Mol, Milan, Italy. Eccles, D. M., Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England. Tang, N., Chinese Univ Hong Kong, Dept Chem Pathol, Hong Kong, Hong Kong, Peoples R China. Olah, E., Natl Inst Oncol, Budapest, Hungary. Anton-Culver, H., Univ Calif Irvine, Dept Med, Div Epidemiol, Irvine, CA USA. Gronwald, J.; Gorski, B., Pomeranian Acad Med, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland. Syrjakoski, K.; Kallioniemi, O-P, Tampere Univ Hosp, Inst Med Technol, Canc Genet Lab, Tampere, Finland. Nevanlinna, H.; Pharoah, P. D. P., Helsinki Univ Central Hosp, Dept Obstet & Gynecol, Helsinki, Finland. Pharoah, P. D. P., Univ Cambridge, Dept Oncol, Human Canc Genet Grp, Canc Res UK, Cambridge, England. keywords: BRCA1; BRCA2; cancer risk model; genetic testing keywords-plus: BRCA2 MUTATION CARRIERS; GENOME-WIDE ASSOCIATION; PROSTATE-CANCER; GERMLINE MUTATIONS; FAMILY-HISTORY; RISK; POPULATION; PENETRANCE; ALLELES; PROBABILITIES research-areas: Oncology web-of-science-categories: Oncology author-email: researcherid-numbers: Kallioniemi, Olli/H-4738-2012 Kallioniemi, Olli/H-5111-2011 Tang, Nelson/P-5018-2017 manoukian, siranoush/E-7132-2017 Gronwald, Jacek/A-4576-2017 Vinnicombe, Sarah/C-2606-2012 orcid-numbers: Kallioniemi, Olli/0000-0002-3231-0332 Kallioniemi, Olli/0000-0002-3231-0332 Tang, Nelson/0000-0002-3607-5819 manoukian, siranoush/0000-0002-6034-7562 Gronwald, Jacek/0000-0002-3643-2871 Tryggvadottir, Laufey/0000-0001-8067-9030 Southey, Melissa/0000-0002-6313-9005 Evans, Gareth/0000-0002-8482-5784 Nevanlinna, Heli/0000-0002-0916-2976 Radice, Paolo/0000-0001-6298-4111 funding-acknowledgement: Associazione Italiana per la Ricerca sul Cancro; NCI NIH HHS [R01 CA 63678, R01 CA063682, R01 CA 63682, R01 CA063678]; Cancer Research UK [10118] number-of-cited-references: 56 times-cited: 211 usage-count-last-180-days: 0 usage-count-since-2013: 13 journal-iso: Br. J. Cancer doc-delivery-number: 288SU unique-id: ISI:000255006900022 oa: gold_or_bronze da: 2018-08-30en_US
pubs.notesNot knownen_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorPeto, Julianen_US

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