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dc.contributor.authorVeglia, Fen_US
dc.contributor.authorLoft, Sen_US
dc.contributor.authorMatullo, Gen_US
dc.contributor.authorPeluso, Men_US
dc.contributor.authorMunnia, Aen_US
dc.contributor.authorPerera, Fen_US
dc.contributor.authorPhillips, DHen_US
dc.contributor.authorTang, Den_US
dc.contributor.authorAutrup, Hen_US
dc.contributor.authorRaaschou-Nielsen, Oen_US
dc.contributor.authorTjonneland, Aen_US
dc.contributor.authorVineis, Pen_US
dc.contributor.authorInvest, GEPICen_US
dc.identifier.citationCARCINOGENESIS, 2008, 29 pp. 932 - 936en_US
dc.description.abstractBulky DNA adducts are biomarkers of exposure to aromatic compounds and of the ability of the individual to metabolically activate carcinogens and to repair DNA damage. Their ability to predict cancer onset is uncertain. We have performed a pooled analysis of three prospective studies on cancer risk in which bulky DNA adducts have been measured in blood samples collected from healthy subjects (N = 1947; average follow-up 51-137 months). In addition, we have performed a meta-analysis by identifying all articles on the same subject published up to the end of 2006, including case-control studies. In the pooled analysis, a weakly statistically significant increase in the risk of lung cancer was apparent (14% per unit standard deviation change in adduct levels, 95% confidence interval 1-28%; using the weighted mean difference method, 0.15 SD, units higher adducts in cases than in controls). The association was evident only in current smokers and was absent in former smokers. Also the meta-analysis, which included both lung and bladder cancers, showed a statistically significant association in current smokers, whereas the results in never smokers were equivocal; in former smokers, no association was detected. The results of our pooled and meta-analyses suggest that bulky DNA adducts are associated with lung cancer arising in current smokers after a follow-up of several years.en_US
dc.format.extent932 - 936en_US
dc.publisherOXFORD UNIV PRESSen_US
dc.titleDNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysisen_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
pubs.notesaffiliation: Vineis, P (Reprint Author), ISI Fdn, Life Sci & Epidemiol Unit, I-10133 Turin, Italy. Veglia, Fabrizio; Matullo, Giuseppe; Vineis, Paolo, ISI Fdn, Life Sci & Epidemiol Unit, I-10133 Turin, Italy. Loft, Steffen, Univ Copenhagen, Dept Environm & Occupat Hlth, DK-1014 Copenhagen, Denmark. Peluso, Marco; Munnia, Armelle, CSPO Sci Inst Tuscany, Mol Biol Lab, Canc Risk Factor Branch, I-50131 Florence, Italy. Perera, Frederica; Tang, Deliang, Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA. Phillips, David H., Inst Canc Res, Sutton SM2 5NG, Surrey, England. Autrup, Herman, Univ Aarhus, Dept Environm & Occupat Med, DK-8000 Aarhus, Denmark. Raaschou-Nielsen, Ole; Tjonneland, Anne, Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen, Denmark. Vineis, Paolo, Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London W2 1PG, England. keywords-plus: WHITE BLOOD-CELLS; LUNG-CANCER; AIR-POLLUTION; ALVEOLAR MACROPHAGES; HEAVY SMOKERS; EXPOSURE; HUMANS; DAMAGE; LYMPHOCYTES; BIOMARKERS research-areas: Oncology web-of-science-categories: Oncology author-email: [email protected] researcherid-numbers: Linseisen, Jakob/B-5353-2014 Hainaut, Pierre/B-6018-2012 Krogh, Vittorio/K-2628-2016 Veglia, Fabrizio/K-1958-2016 Peluso, Marco/I-5187-2018 Matullo, Giuseppe/K-6383-2016 Clavel-Chapelon, Francoise/G-6733-2014 orcid-numbers: Linseisen, Jakob/0000-0002-9386-382X Hainaut, Pierre/0000-0002-1303-1610 Krogh, Vittorio/0000-0003-0122-8624 Veglia, Fabrizio/0000-0002-9378-8874 Peluso, Marco/0000-0001-7646-7967 Matullo, Giuseppe/0000-0003-0674-7757 Tjonneland, Anne/0000-0003-4385-2097 Loft, Steffen/0000-0001-9552-8518 Phillips, David/0000-0001-8509-3485 number-of-cited-references: 30 times-cited: 57 usage-count-last-180-days: 0 usage-count-since-2013: 6 journal-iso: Carcinogenesis doc-delivery-number: 325GI unique-id: ISI:000257576600009 oa: gold_or_bronze da: 2018-08-30en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Human Biomonitoring & Carcinogen Activation
pubs.embargo.termsNot knownen_US
icr.researchteamHuman Biomonitoring & Carcinogen Activationen_US
dc.contributor.icrauthorPhillips, David Hunteren_US

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