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dc.contributor.authorHooper, Jen_US
dc.contributor.authorMaurice, Den_US
dc.contributor.authorArgent-Katwala, MJGen_US
dc.contributor.authorWeston, Ken_US
dc.identifier.citationIMMUNOLOGY, 2008, 123 pp. 282 - 289en_US
dc.description.abstractThe c-myb gene encodes a transcription factor required for the normal development of T cells in the thymus, and for subsequent peripheral T-cell activation and survival. However, the profile of genes known to be transcriptionally regulated by c-Myb in T cells does not adequately explain the pleiotrophic nature of the effects of c-Myb. We present here a detailed molecular characterization of the regulation of a novel target gene, the histone variant H2A.Z. We show that c-Myb is able to bind to and activate the H2A.Z promoter in T cells both in vitro and in vivo, and present evidence that perturbation of Myb activity during T-cell development results in reduced H2A.Z expression. As H2A.Z is absolutely required for the early stages of mammalian development, and plays essential roles in the regulation of chromatin structure in gene promoters in yeast, its regulation by c-Myb is likely to be of some importance during T-cell development.en_US
dc.format.extent282 - 289en_US
dc.titleMyb proteins regulate expression of histone variant H2A.Z during thymocyte developmenten_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
pubs.notesaffiliation: Weston, K (Reprint Author), Inst Canc Res, CRUK Ctr Cell & Mol Biol, 237 Fulham Rd, London SW3 6JB, England. Hooper, Joel; Maurice, Diane; Argent-Katwala, Mary J. G.; Weston, Kathleen, Inst Canc Res, CRUK Ctr Cell & Mol Biol, London SW3 6JB, England. keywords: Myb; H2A.Z; T cells; transcription keywords-plus: T-CELL DEVELOPMENT; C-MYB; V-MYB; SACCHAROMYCES-CEREVISIAE; PROMOTER ACTIVITY; TRANSGENIC MICE; GENE; ACETYLATION; SEQUENCE; HETEROCHROMATIN research-areas: Immunology web-of-science-categories: Immunology author-email: number-of-cited-references: 49 times-cited: 3 usage-count-last-180-days: 0 usage-count-since-2013: 3 journal-iso: Immunology doc-delivery-number: 249EA unique-id: ISI:000252208800014 oa: gold_or_bronze da: 2018-08-30en_US
pubs.notesNot knownen_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorMaurice, Dianeen_US
dc.contributor.icrauthorWeston, Kathleenen_US

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