Publications Repository

Publications Repository

View item 
  •   Home
  • ICR Divisions
  • Clinical Studies
  • View item
  • Home
  • ICR Divisions
  • Clinical Studies
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

The t(14;19)(q32;q13)-positive small B-cell leukaemia: a clinicopathologic and cytogenetic study of seven cases

Thumbnail
Date
2006-11-27
ICR Author
Catovsky, Daniel
Matutes, Estella
Wotherspoon, Andrew
Author
Huh, YO
Abruzzo, LV
Rassidakis, GZ
Parry-Jones, N
Schlette, E
Brito-Bapabulle, V
Matutes, E
Wotherspoon, A
Keating, MJ
Medeiros, LJ
Catovsky, D
Show allShow less
Type
Journal Article
Metadata
Show full item record
Abstract
Summary The t(14;19)(q32;q13), involving the BCL3 locus at chromosome 19q13 and the immunoglobulin heavy chain gene at 14q32, is a rare recurrent cytogenetic abnormality identified in B-cell neoplasms, most of which have been classified as chronic lymphocytic leukaemia (CLL) in the literature. We describe the clinicopathological, immunophenotypic and cytogenetic findings in seven patients with B-cell neoplasms associated with t(14;19)(q32;q13). There were five men and two women, with a median age of 48?years (range 33?68). All had absolute lymphocytosis, six had lymphadenopathy, and one had splenomegaly. Lymphocytes in blood and bone marrow aspirate smears were predominantly small and cytologically atypical. Flow cytometric immunophenotyping showed an atypical immunophenotype with low CLL scores. The growth pattern in bone marrow biopsy specimens was interstitial to diffuse; immunohistochemical stains were positive for bcl3 and negative for cyclin D1. Lymph node biopsy specimens of two patients revealed total architectural effacement by neoplasm with proliferation centres. In addition to t(14;19), cytogenetic studies demonstrated trisomy 12 in five patients. These results suggest that B-cell neoplasms with the t(14;19)(q32;q13) present frequently as leukaemia composed of small B-lymphocytes and share many features with CLL. However, these neoplasms also differ from CLL cytologically and in their immunophenotype.
URI
https://repository.icr.ac.uk/handle/internal/2481
DOI
https://doi.org/10.1111/j.1365-2141.2006.06416.x
Collections
  • Clinical Studies
  • Molecular Pathology
Subject
t(14;19)
chronic lymphocytic leukaemia
atypical morphology
immunophenotype
bcl3
Research team
Molecular Haematology (including Cytogenetics Group and Cell Markers)
Language
eng
License start date
2006-11-27
Citation
British Journal of Haematology, 2006, 136 (2), pp. 220 - 228
Publisher
Wiley/Blackwell (10.1111)

Browse

All of ICR repositoryICR DivisionsBy issue dateAuthorsTitlesPublication TypesThis collectionBy issue dateAuthorsTitlesPublication Types
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.