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dc.contributor.authorMartró, E
dc.contributor.authorEsteve, A
dc.contributor.authorSchulz, TF
dc.contributor.authorSheldon, J
dc.contributor.authorGambús, G
dc.contributor.authorMuñoz, R
dc.contributor.authorWhitby, D
dc.contributor.authorCasabona, J
dc.identifier.citationInt. J. Cancer, 2007, 120 (5), pp. 1129 - 1135
dc.description.abstractAbstract We aimed to identify risk factors for Kaposi's sarcoma (KS) among HIV-positive patients and behaviors associated with human Herpesvirus 8 (HHV-8) infection, as well as to assess KS incidence and mortality rates longitudinally. To fulfill the first objective, a European case-control study was designed in the early 1990s (each KS case was matched to 2 controls with another AIDS indicative disease). After the discovery of HHV-8, serology testing enabled us to assess risk factors for KS development among HHV-8 and HIV-1 coinfected men who have sex with men (MSM), as well as risk factors for HHV-8 infection. HHV-8 seroprevalence was determined using a latent immunofluorescence assay. Relevant information was obtained by means of a questionnaire and medical charts review. Assessment of risk factors for KS development and HHV-8 infection was performed using conditional and unconditional logistic regression models, respectively. A low CD4 count was the only significant risk factor for KS. HHV-8 infection was most strongly linked to the number of life-time sex partners, and multiple body fluids such as saliva and semen are quite likely involved in sexual transmission. Longitudinal follow up showed a significant protective role for highly-active antiretroviral therapy (HAART) both on KS development and mortality of KS patients. Although more conclusive data from cohort studies are needed to better define specific transmission mechanisms for HHV-8, our results contribute to explain why KS incidence is higher among MSM, and the decreasing KS incidence trend observed in countries with universal access to HAART. ? 2006 Wiley-Liss, Inc.
dc.format.extent1129 - 1135
dc.subjecthuman herpesvirus 8
dc.subjectKaposi's sarcoma
dc.subjectrisk factors
dc.subjectbehavioral determinants
dc.subjectcase-control study
dc.titleRisk factors for human Herpesvirus 8 infection and AIDS-associated Kaposi's sarcoma among men who have sex with men in a European multicentre study
dc.typeJournal Article
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfInt. J. Cancer
pubs.notesdoi: 10.1002/ijc.22281
pubs.notesNot known
pubs.embargo.termsNot known
dc.contributor.icrauthorWhitby, Denise

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