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dc.contributor.authorMaurice, Den_US
dc.contributor.authorHooper, Jen_US
dc.contributor.authorLang, Gen_US
dc.contributor.authorWeston, Ken_US
dc.identifier.citationEMBO JOURNAL, 2007, 26 pp. 3629 - 3640en_US
dc.description.abstractDuring T-cell development, thymocytes with intermediate avidity for antigen-MHC complexes are positively selected and then differentiate into functional cytotoxic and helper T cells. This process is controlled by signalling from the T-cell receptor (TCR). Here, we show that the c-Myb transcription factor is a critical downstream regulator of positive selection, promoting the development of helper T cells and blocking the development of cytotoxic T cells. A gain-of-function c-Myb transgene stops development of cytotoxic T cells, instead causing accumulation of a precursor population. Conversely, loss of c-Myb in selecting cells results in significantly fewer helper T cells. In c-Myb-null thymocytes, Gata3, a critical inducer of T-helper cell fate, is not upregulated in response to T-cell receptor signaling, following selection. We show that Gata3 is a direct target of c-Myb, and propose that c-Myb is an important regulator of Gata3, required for transduction of the T-cell receptor signal for subsequent helper cell lineage differentiation.en_US
dc.format.extent3629 - 3640en_US
dc.titlec-Myb regulates lineage choice in developing thymocytes via its target gene Gata3en_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfEMBO JOURNALen_US
pubs.notesaffiliation: Weston, K (Reprint Author), Canc Res UK Ctr Cell & Mol Biol, Inst Canc Res, London, England. Canc Res UK Ctr Cell & Mol Biol, Inst Canc Res, London, England. keywords: CD4; Gata3; Myb; T cell; transcription keywords-plus: T-CELL DEVELOPMENT; TRANSGENIC MICE; TRANSCRIPTION FACTOR; NEGATIVE SELECTION; V-MYB; POSITIVE SELECTION; RUNX PROTEINS; EXPRESSION; CD4; COMMITMENT research-areas: Biochemistry & Molecular Biology; Cell Biology web-of-science-categories: Biochemistry & Molecular Biology; Cell Biology author-email: number-of-cited-references: 48 times-cited: 49 usage-count-last-180-days: 0 usage-count-since-2013: 4 journal-iso: Embo J. doc-delivery-number: 199DI unique-id: ISI:000248676000011 oa: gold_or_bronze da: 2018-08-30en_US
pubs.notesNot knownen_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorLang, Georginaen_US
dc.contributor.icrauthorMaurice, Dianeen_US
dc.contributor.icrauthorWeston, Kathleenen_US

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