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Do all patients with bilateral testis cancer have a hereditary predisposition?

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Date
2007-08-09
ICR Author
Rapley, Elizabeth
Author
Harland, SJ
Rapley, EA
Nicholson, PW
Type
Journal Article
Metadata
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Abstract
Summary An international study has demonstrated that patients with bilateral testicular cancer are significantly more likely to have brothers with testis cancer than those with unilateral disease. This, together with other evidence, implies that patients with bilateral disease are likely to carry a predisposing genotype. But is it the great majority of them which is thus predisposed? We show that if as few as half of these patients have the predisposing genotype, its penetrance would have to be 80%, causing 38% of resulting cases to be bilateral. Evidence from the International Testis Cancer Linkage Consortium shows that the proportion of familial cases with bilateral disease is much lower. It is likely that at least the majority of cases of bilateral testis cancer arise as a result of a predisposing genotype.
URI
https://repository.icr.ac.uk/handle/internal/2492
DOI
https://doi.org/10.1111/j.1365-2605.2007.00801.x
Collections
  • Breast Cancer Research
  • Genetics and Epidemiology
Subject
bilateral
familial
hereditary
testis cancer
Research team
Genetic Susceptibility
Language
eng
License start date
2007-08-09
Citation
International Journal of Andrology, 2007, 30 (4), pp. 251 - 255
Publisher
Wiley/Blackwell (10.1111)

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