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dc.contributor.authorHarland, SJ
dc.contributor.authorRapley, EA
dc.contributor.authorNicholson, PW
dc.date.accessioned2018-08-31T14:56:53Z
dc.date.issued2007-08-09
dc.identifierhttps://doi.org/10.1111/j.1365-2605.2007.00801.x
dc.identifier.citationInternational Journal of Andrology, 2007, 30 (4), pp. 251 - 255
dc.identifier.issn0105-6263
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2492
dc.identifier.doi10.1111/j.1365-2605.2007.00801.x
dc.description.abstractSummary An international study has demonstrated that patients with bilateral testicular cancer are significantly more likely to have brothers with testis cancer than those with unilateral disease. This, together with other evidence, implies that patients with bilateral disease are likely to carry a predisposing genotype. But is it the great majority of them which is thus predisposed? We show that if as few as half of these patients have the predisposing genotype, its penetrance would have to be 80%, causing 38% of resulting cases to be bilateral. Evidence from the International Testis Cancer Linkage Consortium shows that the proportion of familial cases with bilateral disease is much lower. It is likely that at least the majority of cases of bilateral testis cancer arise as a result of a predisposing genotype.
dc.format.extent251 - 255
dc.languageeng
dc.language.isoeng
dc.publisherWiley/Blackwell (10.1111)
dc.subjectbilateral
dc.subjectfamilial
dc.subjecthereditary
dc.subjecttestis cancer
dc.titleDo all patients with bilateral testis cancer have a hereditary predisposition?
dc.typeJournal Article
rioxxterms.versionofrecord10.1111/j.1365-2605.2007.00801.x
rioxxterms.licenseref.startdate2007-08-09
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfInternational Journal of Andrology
pubs.issue4
pubs.notesdoi: 10.1111/j.1365-2605.2007.00801.x
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility
pubs.volume30
pubs.embargo.termsNot known
icr.researchteamGenetic Susceptibilityen_US
dc.contributor.icrauthorRapley, Elizabethen


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