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dc.contributor.authorWang, TFen_US
dc.contributor.authorHorsley, SWen_US
dc.contributor.authorLee, KFen_US
dc.contributor.authorChu, SCen_US
dc.contributor.authorLi, CCen_US
dc.contributor.authorKao, RHen_US
dc.date.accessioned2018-09-04T09:00:53Z
dc.date.issued2006-06en_US
dc.identifier3en_US
dc.identifier.citationCLINICAL AND LABORATORY HAEMATOLOGY, 2006, 28 pp. 160 - 163en_US
dc.identifier.issn0141-9854en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2526
dc.identifier.doi10.1111/j.1365-2257.2006.00770.xen_US
dc.description.abstractCytogenetic abnormalities are observed in approximately two-thirds of patients with acute myeloid leukemia (AML). Chromosome rearrangements are associated with specific subtypes of AML and associated prognosis. We report a patient with AML, M2, who was primarily refractory to standard induction chemotherapy with idarubicin and cytarabine. Flow cytometry of a bone marrow aspirate showed aberrant expression of B-cell markers including CD19. Cytogenetic studies disclosed a translocation between 5q35 and 11q13. Fluorescence in situ hybridization analyses demonstrated that neither the NSD1 nor MLL genes were involved in this case. Further study is required to define conclusively the genes involved and their contribution to pathogenesis in this case.en_US
dc.format.extent160 - 163en_US
dc.titleTranslocation between chromosome 5q35 and chromosome 11q13 - an unusual cytogenetic finding in a primary refractory acute myeloid leukemiaen_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1111/j.1365-2257.2006.00770.xen_US
rioxxterms.licenseref.startdate2006-06en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCLINICAL AND LABORATORY HAEMATOLOGYen_US
pubs.notesunique-id: ISI:000237605000003en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume28en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorHorsley, Sen_US


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