dc.contributor.author | Mourtada-Maarabouni, M | |
dc.contributor.author | Keen, J | |
dc.contributor.author | Clark, J | |
dc.contributor.author | Cooper, CS | |
dc.contributor.author | Williams, GT | |
dc.date.accessioned | 2018-09-04T11:45:28Z | |
dc.date.issued | 2006-06-10 | |
dc.identifier | 10 | |
dc.identifier.citation | EXPERIMENTAL CELL RESEARCH, 2006, 312 pp. 1745 - 1752 | |
dc.identifier.issn | 0014-4827 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2527 | |
dc.identifier.doi | 10.1016/j.yexcr.2006.02.009 | |
dc.description.abstract | RBM5 (RNA-binding motif protein 5/LUCA-15/H37) is encoded at the lung cancer tumor suppressor locus 3p21.3 and itself has several important characteristics of a tumor suppressor, including both potentiation of apoptosis and inhibition of the cell cycle. Here, we report the effects of both upregulation and downregulation of LUCA-15/RBM5 on gene expression monitored using cDNA microarrays. Many of the genes modulated by LUCA-15/ RBM5 are involved in the control of apoptosis, the cell cycle, or both. These effects were confirmed for the most significant genes using real-time RT-PCR and/or Western blotting. In particular, LUCA-15/RBM5 increased the expression of Stat5b and BMP5 and decreased the expression ofAIB1 (Amplified In Breast Cancer 1), proto-oncogene Pim-1, caspase antagonist BIRC3 (cIAP-2, MIHC), and CDK2 (cyclin-dependent kinase 2). These effects on multiple genes controlling both apoptosis and proliferation are in line with the functional effects of LUCA-15/RBM5 and indicate that it plays a central role in regulating cell fate consistent with its tumor suppressor activity. (c) 2006 Elsevier Inc. All rights reserved. | |
dc.format.extent | 1745 - 1752 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.title | Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1016/j.yexcr.2006.02.009 | |
rioxxterms.licenseref.startdate | 2006-06-10 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | EXPERIMENTAL CELL RESEARCH | |
pubs.notes | orcid-numbers: Williams, Gwyn/0000-0003-4556-9930 unique-id: ISI:000238179100006 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Cell Transformation | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Cell Transformation | |
pubs.volume | 312 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Cell Transformation | en_US |
dc.contributor.icrauthor | Cooper, Colin | en |