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dc.contributor.authorMourtada-Maarabouni, M
dc.contributor.authorKeen, J
dc.contributor.authorClark, J
dc.contributor.authorCooper, CS
dc.contributor.authorWilliams, GT
dc.date.accessioned2018-09-04T11:45:28Z
dc.date.issued2006-06-10
dc.identifier10
dc.identifier.citationEXPERIMENTAL CELL RESEARCH, 2006, 312 pp. 1745 - 1752
dc.identifier.issn0014-4827
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2527
dc.identifier.doi10.1016/j.yexcr.2006.02.009
dc.description.abstractRBM5 (RNA-binding motif protein 5/LUCA-15/H37) is encoded at the lung cancer tumor suppressor locus 3p21.3 and itself has several important characteristics of a tumor suppressor, including both potentiation of apoptosis and inhibition of the cell cycle. Here, we report the effects of both upregulation and downregulation of LUCA-15/RBM5 on gene expression monitored using cDNA microarrays. Many of the genes modulated by LUCA-15/ RBM5 are involved in the control of apoptosis, the cell cycle, or both. These effects were confirmed for the most significant genes using real-time RT-PCR and/or Western blotting. In particular, LUCA-15/RBM5 increased the expression of Stat5b and BMP5 and decreased the expression ofAIB1 (Amplified In Breast Cancer 1), proto-oncogene Pim-1, caspase antagonist BIRC3 (cIAP-2, MIHC), and CDK2 (cyclin-dependent kinase 2). These effects on multiple genes controlling both apoptosis and proliferation are in line with the functional effects of LUCA-15/RBM5 and indicate that it plays a central role in regulating cell fate consistent with its tumor suppressor activity. (c) 2006 Elsevier Inc. All rights reserved.
dc.format.extent1745 - 1752
dc.languageeng
dc.language.isoeng
dc.titleCandidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/j.yexcr.2006.02.009
rioxxterms.licenseref.startdate2006-06-10
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfEXPERIMENTAL CELL RESEARCH
pubs.notesorcid-numbers: Williams, Gwyn/0000-0003-4556-9930 unique-id: ISI:000238179100006
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Cell Transformation
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Cell Transformation
pubs.volume312
pubs.embargo.termsNot known
icr.researchteamCell Transformationen_US
dc.contributor.icrauthorCooper, Colinen


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