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dc.contributor.authorKearney, Len_US
dc.date.accessioned2018-09-04T11:48:41Z
dc.date.issued2006-01en_US
dc.identifier.citationCytogenetic and genome research, 2006, 114 (3-4), pp. 189 - 198en_US
dc.identifier.issn1424-8581en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2538
dc.identifier.eissn1424-859Xen_US
dc.identifier.doi10.1159/000094202en_US
dc.description.abstractMultiplex FISH (M-FISH) represents one of the most significant developments in molecular cytogenetics of the past decade. Originally designed to generate 24 colour karyotyping, the technique has spawned many variations and an equally diverse range of applications. In tumour and leukaemia cytogenetics, the two groups that have been targeted represent both ends of the cytogenetic spectrum: those with an apparently normal karyotype (suspected of harbouring small rearrangements not detectable by conventional cytogenetics) and those with a complex aberrant karyotype (which are difficult to karyotype accurately due to the sheer number of aberrations). In research, mouse M-FISH provides a powerful tool to characterize mouse models of a disease. In addition, the ability to accurately karyotype single metaphases without selection makes M-FISH the perfect tool in chromosome breakage studies and for characterizing clonal evolution of tumours. Finally, M-FISH has emerged as the perfect partner for the developing genomic microarray (array CGH) technologies, providing a powerful approach to gene discovery.en_US
dc.formatPrinten_US
dc.format.extent189 - 198en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectHumansen_US
dc.subjectBurkitt Lymphomaen_US
dc.subjectChromosome Aberrationsen_US
dc.subjectTranslocation, Geneticen_US
dc.subjectIn Situ Hybridization, Fluorescenceen_US
dc.subjectKaryotypingen_US
dc.subjectCytogeneticsen_US
dc.titleMultiplex-FISH (M-FISH): technique, developments and applications.en_US
dc.typeJournal Article
dcterms.dateAccepted2006-04-06en_US
rioxxterms.versionofrecord10.1159/000094202en_US
rioxxterms.licenseref.startdate2006-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCytogenetic and genome researchen_US
pubs.issue3-4en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Biology of Childhood Leukaemia
pubs.volume114en_US
pubs.embargo.termsNot knownen_US
icr.researchteamBiology of Childhood Leukaemiaen_US
dc.contributor.icrauthorKearney, Lyndal Unaen_US


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