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dc.contributor.authorFraser, LRen_US
dc.contributor.authorAdeoya-Osiguwa, SAen_US
dc.contributor.authorBaxendale, RWen_US
dc.contributor.authorGibbons, Ren_US
dc.identifier.citationFRONTIERS IN BIOSCIENCE-LANDMARK, 2006, 11 pp. 1636 - 1645en_US
dc.description.abstractCapacitation in vitro in mammalian spermatozoa can be regulated by a number of first messengers, including fertilization promoting peptide, adenosine, calcitonin and angiotensin II, all of which are found in seminal plasma. The responses appear to involve several separate signal transduction pathways that have a common end point. These seminal-plasma derived first messengers can bind to specific receptors and directly or indirectly modulate the activity of membrane-associated adenylyl cyclase isoforms and production of the second messenger cAMP. Responses to all of these except angiotensin II involve initial acceleration of cAMP production and capacitation followed by inhibition of both cAMP production and spontaneous acrosome loss, resulting in maintenance of fertilizing potential. Appropriate G proteins and various phosphodiesterase isoforms also appear to be involved. The transition from stimulatory to inhibitory responses involves loss of decapacitation factors (DF) from receptors (DF-R) on the external surface; a DF-R present on both mouse and human spermatozoa has recently been identified as phosphatidylethanolamine-binding protein 1. The presence/ absence of DF appears to cause changes in the plasma membrane that then alter the functionality of various membrane-associated proteins, including receptors. Since spermatozoa contact these first messengers at ejaculation, it is plausible that their actions observed in vitro also occur in vivo, allowing these molecules to play a pivotal role in enhancing the chances of successful fertilization.en_US
dc.format.extent1636 - 1645en_US
dc.titleRegulation of mammalian sperm capacitation by endogenous moleculesen_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
pubs.notesaffiliation: Fraser, LR (Reprint Author), Kings Coll London, Sch Biomed & Hlth Sci, Reprod & Rhythms Grp, Guys Campus, London SE1 1UL, England. Kings Coll London, Sch Biomed & Hlth Sci, Reprod & Rhythms Grp, London SE1 1UL, England. Inst Canc Res, London SW3 6JB, England. keywords: egg; ovum; capacitation; fertilization; sperm; spermatozoa; decapacitation factor; GPCR; G proteins; mAC; PDE; PEBP 1; review keywords-plus: PROTEIN-TYROSINE PHOSPHORYLATION; FERTILIZATION-PROMOTING PEPTIDE; ADENYLYL-CYCLASE ISOFORMS; ANGIOTENSIN-II; MOUSE SPERM; DECAPACITATION FACTOR; ACROSOME REACTION; ADENOSINE RECEPTORS; HUMAN SPERMATOZOA; CAMP PRODUCTION research-areas: Biochemistry & Molecular Biology; Cell Biology web-of-science-categories: Biochemistry & Molecular Biology; Cell Biology author-email: funding-acknowledgement: Wellcome Trust number-of-cited-references: 49 times-cited: 26 usage-count-last-180-days: 2 usage-count-since-2013: 8 journal-iso: Front. Biosci. doc-delivery-number: 996NG unique-id: ISI:000234180200038 da: 2018-09-04en_US
pubs.notesNot knownen_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorBaxendale, Rhonaen_US

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