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dc.contributor.authorMilligan, DW
dc.contributor.authorKochethu, G
dc.contributor.authorDearden, C
dc.contributor.authorMatutes, E
dc.contributor.authorMacConkey, C
dc.contributor.authorCatovsky, D
dc.contributor.authorGrp, NCRIHS
dc.date.accessioned2018-09-04T13:10:23Z
dc.date.issued2006-04
dc.identifier2
dc.identifier.citationBRITISH JOURNAL OF HAEMATOLOGY, 2006, 133 pp. 173 - 175
dc.identifier.issn0007-1048
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2549
dc.identifier.doi10.1111/j.1365-2141.2006.05982.x
dc.description.abstractWe report a high incidence of myelodysplastic syndrome (MDS)/acute myeloid leukaemia (AML) in patients entered into the Medical Research Council Chronic Lymphocytic Leukaemia-5 trial. Of 115 newly diagnosed patients treated with fludarabine, 65 patients proceeded to autologous transplant. Conditioning was cyclophosphamide and total body irradiation in 49 (75%) patients and chemotherapy in 12 (18%). Ten patients have developed MDS/AML; eight had undergone an autograft. Five-year actuarial risk of developing MDS/AML postautograft was 12.4% (95% confidence interval, 2.5-24%). No analysed potential risk factor was predictive for MDS/AML development. We hypothesise that potential causative factors are fludarabine, low cell dose and transplant conditioning.
dc.format.extent173 - 175
dc.languageeng
dc.language.isoeng
dc.publisherBLACKWELL PUBLISHING
dc.titleHigh incidence of myelodysplasia and secondary leukaemia in the UK Medical Research Council Pilot of autografting in chronic lymphocytic leukaemia
dc.typeJournal Article
rioxxterms.versionofrecord10.1111/j.1365-2141.2006.05982.x
rioxxterms.licenseref.startdate2006-04
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBRITISH JOURNAL OF HAEMATOLOGY
pubs.notesaffiliation: Milligan, DW (Reprint Author), Birmingham Heartlands Hosp, Dept Haematol, Birmingham B9 5SS, W Midlands, England. Birmingham Heartlands Hosp, Dept Haematol, Birmingham B9 5SS, W Midlands, England. Royal Marsden Hosp, Dept Acad Haematol, London SW3 6JJ, England. Univ Birmingham, Inst Canc Studies, Birmingham B15 2TT, W Midlands, England. keywords: autologous stem cell transplantation; secondary leukaemia and myelodysplasia; chronic lymphocytic leukaemia keywords-plus: BONE-MARROW-TRANSPLANTATION; THERAPY; FLUDARABINE; LYMPHOMA; CHLORAMBUCIL research-areas: Hematology web-of-science-categories: Hematology author-email: [email protected] number-of-cited-references: 13 times-cited: 20 usage-count-last-180-days: 0 usage-count-since-2013: 0 journal-iso: Br. J. Haematol. doc-delivery-number: 022PK unique-id: ISI:000236067900007 oa: gold_or_bronze da: 2018-09-04
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.volume133
pubs.embargo.termsNot known
icr.researchteamMolecular Haematology (including Cytogenetics Group and Cell Markers)en_US
dc.contributor.icrauthorCatovsky, Danielen
dc.contributor.icrauthorMatutes, Estellaen
dc.contributor.icrauthorDearden, Claireen


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