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dc.contributor.authorMa, ESF
dc.contributor.authorBates, WD
dc.contributor.authorEdmunds, A
dc.contributor.authorKelland, LR
dc.contributor.authorFojo, T
dc.contributor.authorFarrell, N
dc.date.accessioned2018-09-06T13:03:19Z
dc.date.issued2005-09-08
dc.identifier18
dc.identifier.citationJOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 pp. 5651 - 5654
dc.identifier.issn0022-2623
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2573
dc.identifier.doi10.1021/jm050539d
dc.description.abstractA general approach to solubilization and possible in vivo activation of the transplatinum geometry is presented. The synthesis and characterization of new water-soluble cytotoxic transplatinum compounds are described. Use of acetate ligands (and carboxylate ligands in general) in trans[Pt(OAc)(2)(L)(L’)J results in significantly enhanced aqueous solubility and chemical stability in comparison to the parent dichlorides. The new compounds are the first cytotoxic transplatinum compounds containing an N2O2 donor set, similar to carboplatin and oxaliplatin.
dc.format.extent5651 - 5654
dc.languageeng
dc.language.isoeng
dc.publisherAMER CHEMICAL SOC
dc.titleEnhancement of aqueous solubility and stability employing a trans acetate axis in trans planar amine platinum compounds while maintaining the biological profile
dc.typeJournal Article
rioxxterms.versionofrecord10.1021/jm050539d
rioxxterms.licenseref.startdate2005-09-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfJOURNAL OF MEDICINAL CHEMISTRY
pubs.notesaffiliation: Farrell, N (Reprint Author), Virginia Commonwealth Univ, Dept Chem, Med Coll Virginia Campus, Richmond, VA 23284 USA. Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA. Inst Canc Res, CRC Ctr Canc Therapeut, Sutton SM2 5NG, Surrey, England. NCI, Canc Res Ctr, NIH, Bethesda, MD 20892 USA. keywords-plus: INTERSTRAND CROSS-LINK; HYDROLYSIS PRODUCTS; ANTITUMOR COMPLEXES; CELL-LINES; DNA; CISPLATIN; DRUG; RECOGNITION; KINETICS; PYRIDINE research-areas: Pharmacology & Pharmacy web-of-science-categories: Chemistry, Medicinal author-email: [email protected] number-of-cited-references: 38 times-cited: 44 usage-count-last-180-days: 0 usage-count-since-2013: 6 journal-iso: J. Med. Chem. doc-delivery-number: 962OV unique-id: ISI:000231743000005 da: 2018-09-06
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.volume48
pubs.embargo.termsNot known
dc.contributor.icrauthorKelland, Lloyden


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