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dc.contributor.authorMa, ESFen_US
dc.contributor.authorBates, WDen_US
dc.contributor.authorEdmunds, Aen_US
dc.contributor.authorKelland, LRen_US
dc.contributor.authorFojo, Ten_US
dc.contributor.authorFarrell, Nen_US
dc.date.accessioned2018-09-06T13:03:19Z
dc.date.issued2005-09-08en_US
dc.identifier18en_US
dc.identifier.citationJOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 pp. 5651 - 5654en_US
dc.identifier.issn0022-2623en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2573
dc.identifier.doi10.1021/jm050539den_US
dc.description.abstractA general approach to solubilization and possible in vivo activation of the transplatinum geometry is presented. The synthesis and characterization of new water-soluble cytotoxic transplatinum compounds are described. Use of acetate ligands (and carboxylate ligands in general) in trans[Pt(OAc)(2)(L)(L’)J results in significantly enhanced aqueous solubility and chemical stability in comparison to the parent dichlorides. The new compounds are the first cytotoxic transplatinum compounds containing an N2O2 donor set, similar to carboplatin and oxaliplatin.en_US
dc.format.extent5651 - 5654en_US
dc.languageEnglishen_US
dc.language.isoEnglishen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.titleEnhancement of aqueous solubility and stability employing a trans acetate axis in trans planar amine platinum compounds while maintaining the biological profileen_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1021/jm050539den_US
rioxxterms.licenseref.startdate2005-09-08en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfJOURNAL OF MEDICINAL CHEMISTRYen_US
pubs.notesaffiliation: Farrell, N (Reprint Author), Virginia Commonwealth Univ, Dept Chem, Med Coll Virginia Campus, Richmond, VA 23284 USA. Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA. Inst Canc Res, CRC Ctr Canc Therapeut, Sutton SM2 5NG, Surrey, England. NCI, Canc Res Ctr, NIH, Bethesda, MD 20892 USA. keywords-plus: INTERSTRAND CROSS-LINK; HYDROLYSIS PRODUCTS; ANTITUMOR COMPLEXES; CELL-LINES; DNA; CISPLATIN; DRUG; RECOGNITION; KINETICS; PYRIDINE research-areas: Pharmacology & Pharmacy web-of-science-categories: Chemistry, Medicinal author-email: nfarrell@saturn.vcu.edu number-of-cited-references: 38 times-cited: 44 usage-count-last-180-days: 0 usage-count-since-2013: 6 journal-iso: J. Med. Chem. doc-delivery-number: 962OV unique-id: ISI:000231743000005 da: 2018-09-06en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume48en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorKelland, Lloyden_US


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