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dc.contributor.authorThornton, PDen_US
dc.contributor.authorBellas, Cen_US
dc.contributor.authorSanton, Aen_US
dc.contributor.authorShah, Gen_US
dc.contributor.authorPocock, Cen_US
dc.contributor.authorWotherspoon, ACen_US
dc.contributor.authorMatutes, Een_US
dc.contributor.authorCatovsky, Den_US
dc.identifier.citationLEUKEMIA RESEARCH, 2005, 29 pp. 389 - 395en_US
dc.description.abstractTransformation of CLL into a large cell lymphoma has an incidence of 3-5%. We have studied 101 cases of CLL treated with fludarabine over a 10-year period (1990-2000) and observed a 12% incidence of transformation. In six of 12 patients, transformation was documented within 4 months following treatment with fludarabine. Pathological material, available in nine cases, was investigated for latent EBV by staining for LMP-1 by immunohistochemistry and EBERs-1 and 2 by in situ hybridisation. LMP-1 and EBERs were demonstrated in three of the nine samples. In two cases there was a different pattern of immunoglobulin gene rearrangement in the transformed cells assessed by PCR (FR3 fragment) compared to the original CLL clone. One of these two cases showed evidence of latent EBV. The other seven cases, of which two were EBV positive, showed identical pattern of Ig gene rearrangement in both the CLL and the transformed cells. We suggest that the relatively high incidence of transformation in this series may be due to immunosuppression mainly related to fludarabine, although other agents and prior therapies may have also contributed. (c) 2004 Published by Elsevier Ltd.en_US
dc.format.extent389 - 395en_US
dc.titleRichter’s transformation of chronic lymphocytic leukemia - The possible role of fludarabine and the Epstein-Barr virus in its pathogenesisen_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfLEUKEMIA RESEARCHen_US
pubs.notesaffiliation: Catovsky, D (Reprint Author), Royal Marsden Hosp, Inst Canc Res, Sect Haemato Oncol, Fulham Rd, London SW3 6JJ, England. Royal Marsden Hosp, Inst Canc Res, Sect Haemato Oncol, London SW3 6JJ, England. Hosp Univ Puerta Hierro, Sect Histopathol, Madrid, Spain. Hosp Ramon & Cajal, Sect Histopathol, E-28034 Madrid, Spain. keywords: CLL; Richter’s syndrome; fludarabine; Epstein-Barr virus keywords-plus: STERNBERG-LIKE CELLS; POLYMERASE-CHAIN-REACTION; HODGKINS-DISEASE; LYMPHOPROLIFERATIVE DISORDERS; FOLLICULAR LYMPHOMA; EBV; INFECTION; THERAPY; EXPERIENCE; DELETIONS research-areas: Oncology; Hematology web-of-science-categories: Oncology; Hematology author-email: number-of-cited-references: 34 times-cited: 60 usage-count-last-180-days: 0 usage-count-since-2013: 1 journal-iso: Leuk. Res. doc-delivery-number: 905PP unique-id: ISI:000227581700007 da: 2018-09-06en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular Haematology (including Cytogenetics Group and Cell Markers)en_US
dc.contributor.icrauthorCatovsky, Danielen_US
dc.contributor.icrauthorMatutes, Estellaen_US

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