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dc.contributor.authorOsuji, Nen_US
dc.contributor.authorMatutes, Een_US
dc.contributor.authorMorilla, Aen_US
dc.contributor.authorDel Giudice, Ien_US
dc.contributor.authorWotherspoon, Aen_US
dc.contributor.authorCatovsky, Den_US
dc.date.accessioned2018-09-07T09:04:30Z
dc.date.issued2005-05en_US
dc.identifier5en_US
dc.identifier.citationLEUKEMIA & LYMPHOMA, 2005, 46 pp. 757 - 763en_US
dc.identifier.issn1042-8194en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2585
dc.identifier.doi10.1080/10428190500032273en_US
dc.description.abstractWe describe a case of natural killer (NK) cell leukemia with acute presentation, systemic symptoms and hepatosplenomegaly. The uniform and aberrant phenotype of NK cells with infiltration of bone marrow and spleen was in keeping with a malignant diagnosis. Aggressive presentation was demonstrated by marked constitutional symptoms and significant tumor burden (liver, spleen, blood, bone marrow). The subsequent clinical course has been indolent, but this may have been influenced by treatment. Treatment consisted sequentially of splenectomy, intravenous pentostatin and the combination of cyclosporine A and recombinant human erythropoietin and has resulted in survival of over 48 months. We discuss the difficulties in the diagnosis of this condition, explore possible causes of cytopenia(s), and highlight the role of immunosuppression in controlling disease manifestations in large granular lymphocyte proliferative disorders.en_US
dc.format.extent757 - 763en_US
dc.languageEnglishen_US
dc.language.isoEnglishen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.titleProlonged treatment response in aggressive natural killer cell leukemiaen_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1080/10428190500032273en_US
rioxxterms.licenseref.startdate2005-05en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfLEUKEMIA & LYMPHOMAen_US
pubs.notesaffiliation: Catovsky, D (Reprint Author), Royal Marsden NHS Trust, Inst Canc Res, Sect Haematooncol, Fulham Rd, London SW3 6JJ, England. Royal Marsden NHS Trust, Inst Canc Res, Sect Haematooncol, London SW3 6JJ, England. Royal Marsden NHS Trust, Inst Canc Res, Dept Histopathol, London SW3 6JJ, England. keywords: NK cell leukemia; large granular lymphocytes; cyclosporine; erythropoietin; pentostatin keywords-plus: GRANULAR LYMPHOCYTIC-LEUKEMIA; LARGE ANTIGRANULOCYTES LYMPHOCYTES; T-CELL; PERIPHERAL-BLOOD; CYCLOSPORINE-A; LONG-TERM; NK CELLS; LINEAGE; DISORDERS; THERAPY research-areas: Oncology; Hematology web-of-science-categories: Oncology; Hematology author-email: daniel.catovsky@icr.ac.uk researcherid-numbers: Del Giudice, Ilaria/K-6027-2016 orcid-numbers: Del Giudice, Ilaria/0000-0001-6864-9533 number-of-cited-references: 38 times-cited: 5 usage-count-last-180-days: 0 usage-count-since-2013: 0 journal-iso: Leuk. Lymphoma doc-delivery-number: 933IE unique-id: ISI:000229621300015 da: 2018-09-06en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.volume46en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular Haematology (including Cytogenetics Group and Cell Markers)en_US
dc.contributor.icrauthorCatovsky, Danielen_US
dc.contributor.icrauthorMorilla, Alisonen_US
dc.contributor.icrauthorWotherspoon, Andrewen_US
dc.contributor.icrauthorOsuji, NNennaen_US


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