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dc.contributor.authorOsuji, N
dc.contributor.authorMatutes, E
dc.contributor.authorCatovsky, D
dc.contributor.authorLampert, I
dc.contributor.authorWotherspoon, A
dc.date.accessioned2018-09-07T09:06:52Z
dc.date.issued2005-07
dc.identifier7
dc.identifier.citationAMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2005, 29 pp. 935 - 941
dc.identifier.issn0147-5185
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2587
dc.identifier.eissn1532-0979
dc.identifier.doi10.1097/01.pas.0000160732.43909.3f
dc.description.abstractWe review retrospectively the spleen histology in 8 patients with T-cell large granular lymphocyte (LGL) leukemia and 4 with T-cell prolymphocytic leukemia (T-PLL) to identify characteristic patterns of involvement and to distinguish such patterns from those described in other low grade B- and T-cell malignancies. Moderate splenic enlargement with red pulp expansion due to lymphocytic infiltration was characteristic of LGL leukemia. Abnormal lymphocytes expressed cytotoxic granule proteins and were consistently CD45RO and CD5 negative in contrast to normal red pulp T cells. This infiltration respected anatomic boundaries with encroachment but no invasion of white pulp areas. Unlike in hairy cell leukemia, the main differential diagnosis for red pulp lymphocytosis, the white pulp was not only preserved in T-cell LGL leukemia but showed germinal center hyperplasia with expansion of the mantle zones. By comparison, T-PLL spleens showed marked red pulp lymphoid infiltration by medium-sized cells with irregular nuclei and prominent eosinophilic nucleoli. T-PLL lymphocytes, unlike LGLs, were more invasive, infiltrating the spleen capsule as well as white pulp areas. T-cell prolymphocytes did not express cytotoxic granule proteins or NK-cell markers, were CD5+, CD45RO+ like normal spleen T cells, were CD2+, CD3+, CD45+, CD43+, TCR beta+, but CD25-, CD30-, ALK-1-, TRAP-, DBA44-, and TdT-. Expression of CD4 and CD8 in these cells mirrored that of circulating T-PLL cells. These observations on the morphologic and immunohistochemical appearances of the spleen in T-cell LGL leukemia and T-PLL may aid diagnosis of these uncommon T-cell disorders, particularly T-cell LGL leukemia, where presentation may be cryptic and where unique pathognomonic features, are absent.
dc.format.extent935 - 941
dc.languageeng
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.titleHistopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia - A comparative review
dc.typeJournal Article
rioxxterms.versionofrecord10.1097/01.pas.0000160732.43909.3f
rioxxterms.licenseref.startdate2005-07
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfAMERICAN JOURNAL OF SURGICAL PATHOLOGY
pubs.notesaffiliation: Osuji, N (Reprint Author), Royal Marsden NHS Trust, Sect Haematooncol, Inst Canc Res, Fulham Rd, London SW3 6JJ, England. Royal Marsden Hosp Fdn Trust, Sect Haematooncol, Inst Canc Res, London SW3 6JJ, England. Royal Marsden Hosp Fdn Trust, Dept Histopathol, Inst Canc Res, London SW3 6JJ, England. Hammersmith Hosp, Dept Histopathol, London W12 0HS, England. keywords: spleen; histology; T-PLL; T-cell LGL leukemia keywords-plus: CLINICAL-EVALUATION; PATHOLOGY research-areas: Pathology; Surgery web-of-science-categories: Pathology; Surgery author-email: [email protected] number-of-cited-references: 22 times-cited: 14 usage-count-last-180-days: 0 usage-count-since-2013: 2 journal-iso: Am. J. Surg. Pathol. doc-delivery-number: 939WF unique-id: ISI:000230102600012 da: 2018-09-06
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.volume29
pubs.embargo.termsNot known
icr.researchteamMolecular Haematology (including Cytogenetics Group and Cell Markers)en_US
dc.contributor.icrauthorCatovsky, Danielen
dc.contributor.icrauthorMatutes, Estellaen
dc.contributor.icrauthorWotherspoon, Andrewen


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