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Negative and positive regulation of HIF-1: A complex network

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Date
2005-07-25
ICR Author
Ashcroft, Margaret
Author
Bardos, JI
Ashcroft, M
Type
Journal Article
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Abstract
Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic response in eukaryotic cells, regulating the expression of a myriad of genes involved in oxygen transport, glucose uptake and glycolysis and angiogenesis. Deregulation of HIF-1 activity Occurs in many human cancers, usually at the level of the HIF-1 alpha subunit. HIF-1 is regulated by a variety of mechanisms including transcription, translation post-translational modification, protein-protein interaction and degradation. Our understanding of the key signalling pathways that regulate HIF-1 has significantly progressed in recent years and has highlighted the potential for targeting the HIF-1 pathway as a basis for the development of new cancer therapies. (c) 2005 Elsevier B.V All rights reserved.
URI
https://repository.icr.ac.uk/handle/internal/2590
DOI
https://doi.org/10.1016/j.bbcan.2005.05.001
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  • Other ICR Research
Language
eng
License start date
2005-07-25
Citation
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2005, 1755 pp. 107 - 120
Publisher
ELSEVIER SCIENCE BV

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