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dc.contributor.authorBardos, JIen_US
dc.contributor.authorAshcroft, Men_US
dc.date.accessioned2018-09-07T09:07:12Z
dc.date.issued2005-07-25en_US
dc.identifier2en_US
dc.identifier.citationBIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2005, 1755 pp. 107 - 120en_US
dc.identifier.issn0304-419Xen_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2590
dc.identifier.doi10.1016/j.bbcan.2005.05.001en_US
dc.description.abstractHypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic response in eukaryotic cells, regulating the expression of a myriad of genes involved in oxygen transport, glucose uptake and glycolysis and angiogenesis. Deregulation of HIF-1 activity Occurs in many human cancers, usually at the level of the HIF-1 alpha subunit. HIF-1 is regulated by a variety of mechanisms including transcription, translation post-translational modification, protein-protein interaction and degradation. Our understanding of the key signalling pathways that regulate HIF-1 has significantly progressed in recent years and has highlighted the potential for targeting the HIF-1 pathway as a basis for the development of new cancer therapies. (c) 2005 Elsevier B.V All rights reserved.en_US
dc.format.extent107 - 120en_US
dc.languageEnglishen_US
dc.language.isoEnglishen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.titleNegative and positive regulation of HIF-1: A complex networken_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/j.bbcan.2005.05.001en_US
rioxxterms.licenseref.startdate2005-07-25en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCERen_US
pubs.notesaffiliation: Ashcroft, M (Reprint Author), Inst Canc Res, Ctr Canc Therapeut, Canc Res UK, Cell Growth Regulat & Angiogenesis Lab, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England. Inst Canc Res, Ctr Canc Therapeut, Canc Res UK, Cell Growth Regulat & Angiogenesis Lab, Sutton SM2 5NG, Surrey, England. keywords: hypoxia inducible factor-1; HIF-1 alpha; HIF-2 alpha; hypoxia; growth factors; tumour suppressor protein; oncogenic signalling keywords-plus: HYPOXIA-INDUCIBLE FACTOR; ENDOTHELIAL GROWTH-FACTOR; HIPPEL-LINDAU PROTEIN; FACTOR-I HIF-1; HISTONE DEACETYLASE INHIBITOR; UBIQUITIN-PROTEASOME PATHWAY; FACTOR 1-ALPHA HIF-1-ALPHA; 3-KINASE/PROTEIN KINASE-B; SMALL-MOLECULE INHIBITORS; ARNT TRANSCRIPTION FACTOR research-areas: Biochemistry & Molecular Biology; Biophysics; Oncology web-of-science-categories: Biochemistry & Molecular Biology; Biophysics; Oncology author-email: margaret.ashcroft@icr.ac.uk number-of-cited-references: 197 times-cited: 183 usage-count-last-180-days: 1 usage-count-since-2013: 28 journal-iso: Biochim. Biophys. Acta-Rev. Cancer doc-delivery-number: 950SN unique-id: ISI:000230877800003 da: 2018-09-06en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume1755en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorAshcroft, Margareten_US


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