dc.contributor.author | Oliver, AW | |
dc.contributor.author | Jones, SA | |
dc.contributor.author | Roe, SM | |
dc.contributor.author | Matthews, S | |
dc.contributor.author | Goodwin, GH | |
dc.contributor.author | Pearl, LH | |
dc.date.accessioned | 2018-09-07T09:07:27Z | |
dc.date.issued | 2005-08 | |
dc.identifier.citation | The Biochemical journal, 2005, 389 (Pt 3), pp. 657 - 664 | |
dc.identifier.issn | 0264-6021 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2592 | |
dc.identifier.eissn | 1470-8728 | |
dc.identifier.doi | 10.1042/bj20050310 | |
dc.description.abstract | The BAH domain (bromo-associated homology domain) was first identified from a repeated motif found in the nuclear protein polybromo--a large (187 kDa) modular protein comprising six bromodomains, two BAH domains and an HMG box. To date, the BAH domain has no ascribed function, although it is found in a wide range of proteins that contain additional domains involved in either transcriptional regulation (e.g. SET, PHD and bromodomain) and/or DNA binding (HMG box and AT hook). The molecular function of polybromo itself also remains unclear, but it has been identified as a key component of an SWI/SNF (switching/sucrose non-fermenting)-related, ATP-dependent chromatin-remodelling complex PBAF (polybromo, BRG1-associated factors; also known as SWI/SNF-B or SWI/SNFbeta). We present in this paper the crystal structure of the proximal BAH domain from chicken polybromo (BAH1), at a resolution of 1.6 A (1 A=0.1 nm). Structure-based sequence analysis reveals several features that may be involved in mediating protein-protein interactions. | |
dc.format | Print | |
dc.format.extent | 657 - 664 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.subject | Animals | |
dc.subject | Chickens | |
dc.subject | Nuclear Proteins | |
dc.subject | Transcription Factors | |
dc.subject | Crystallization | |
dc.subject | Sequence Alignment | |
dc.subject | Amino Acid Sequence | |
dc.subject | Conserved Sequence | |
dc.subject | Protein Structure, Tertiary | |
dc.subject | Sequence Homology, Amino Acid | |
dc.subject | Molecular Sequence Data | |
dc.title | Crystal structure of the proximal BAH domain of the polybromo protein. | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1042/bj20050310 | |
rioxxterms.licenseref.startdate | 2005-08 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | The Biochemical journal | |
pubs.issue | Pt 3 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR | |
pubs.publication-status | Published | |
pubs.volume | 389 | |
pubs.embargo.terms | Not known | |
dc.contributor.icrauthor | Pearl, Laurence | en |