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dc.contributor.authorOliver, AWen_US
dc.contributor.authorJones, SAen_US
dc.contributor.authorRoe, SMen_US
dc.contributor.authorMatthews, Sen_US
dc.contributor.authorGoodwin, GHen_US
dc.contributor.authorPearl, LHen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2018-09-07T09:07:27Z
dc.date.issued2005-08-01en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/15839835en_US
dc.identifierBJ20050310en_US
dc.identifier.citationBiochem J, 2005, 389 (Pt 3), pp. 657 - 664en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2592
dc.identifier.eissn1470-8728en_US
dc.identifier.doi10.1042/BJ20050310en_US
dc.description.abstractThe BAH domain (bromo-associated homology domain) was first identified from a repeated motif found in the nuclear protein polybromo--a large (187 kDa) modular protein comprising six bromodomains, two BAH domains and an HMG box. To date, the BAH domain has no ascribed function, although it is found in a wide range of proteins that contain additional domains involved in either transcriptional regulation (e.g. SET, PHD and bromodomain) and/or DNA binding (HMG box and AT hook). The molecular function of polybromo itself also remains unclear, but it has been identified as a key component of an SWI/SNF (switching/sucrose non-fermenting)-related, ATP-dependent chromatin-remodelling complex PBAF (polybromo, BRG1-associated factors; also known as SWI/SNF-B or SWI/SNFbeta). We present in this paper the crystal structure of the proximal BAH domain from chicken polybromo (BAH1), at a resolution of 1.6 A (1 A=0.1 nm). Structure-based sequence analysis reveals several features that may be involved in mediating protein-protein interactions.en_US
dc.format.extent657 - 664en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectAmino Acid Sequenceen_US
dc.subjectAnimalsen_US
dc.subjectChickensen_US
dc.subjectConserved Sequenceen_US
dc.subjectCrystallizationen_US
dc.subjectMolecular Sequence Dataen_US
dc.subjectNuclear Proteinsen_US
dc.subjectProtein Structure, Tertiaryen_US
dc.subjectSequence Alignmenten_US
dc.subjectSequence Homology, Amino Aciden_US
dc.subjectTranscription Factorsen_US
dc.titleCrystal structure of the proximal BAH domain of the polybromo protein.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1042/BJ20050310en_US
rioxxterms.licenseref.startdate2005-08-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBiochem Jen_US
pubs.issuePt 3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.publication-statusPublisheden_US
pubs.volume389en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorPearl, Laurenceen_US


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