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Pregnancy improves neutropenia in T-cell large granular lymphocyte leukaemia

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Date
2005-03
ICR Author
Catovsky, Daniel
Matutes, Estella
Dearden, Claire
Osuji, NNenna
Author
Osuji, N
Matutes, E
Dearden, C
Catovsky, D
Type
Journal Article
Metadata
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Abstract
The effect of pregnancy on T-cell large granular lymphocyte (LGL) leukaemia has not been previously described. We retrospectively reviewed the clinical features of three patients with T-cell LGL leukaemia; each of them had one or more pregnancies during disease evolution. Pregnancy was associated with sustained improvement in neutrophil count and concurrent reduction in lymphocytosis. Neutropenia returned in the non-pregnant state in all cases. A similar effect, induced by exogenous progesterone in one patient, suggests a role for progesterone in overcoming mechanisms of neutropenia in this disease. Pregnancy thus appears to have a beneficial effect on neutrophil count in T-cell LGL leukaemia.
URI
https://repository.icr.ac.uk/handle/internal/2593
DOI
https://doi.org/10.1111/j.1365-2141.2005.05370.x
Collections
  • Clinical Studies
  • Molecular Pathology
Research team
Molecular Haematology (including Cytogenetics Group and Cell Markers)
Language
eng
License start date
2005-03
Citation
BRITISH JOURNAL OF HAEMATOLOGY, 2005, 128 pp. 645 - 648
Publisher
BLACKWELL PUBLISHING LTD

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