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dc.contributor.authorAnderson, TJ
dc.contributor.authorWaller, M
dc.contributor.authorEllis, IO
dc.contributor.authorBobrow, L
dc.contributor.authorMoss, S
dc.date.accessioned2018-09-10T14:07:51Z
dc.date.issued2004
dc.identifier10
dc.identifier.citationHuman Pathology, 2004, 35 pp. 1252 - 1259
dc.identifier.issn0046-8177
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2597
dc.identifier.doi10.1016/j.humpath.2004.07.011
dc.description.abstractThe objective of this study was to determine the influence of annual mammography on pathology features of breast cancers in an invited population. We conducted a randomized trial of 53,890 invited and 106,971 control United Kingdom women who were recruited only from those aged 40 years, with central review of cancer histology. We compare the invasive cancer distribution for the categories of size, histological type, grade, and node status in subgroups of the invited population with that of controls. Among 1287 cancers identified in the total population through the end of December 1999, there are major differences among prevalence, incidence, interval, and lapsed-attender and nonattender subgroups for the distribution of cancer numbers in categories of chosen qualitative histological features. These reflect the biases known to affect a population exposed to screening. Comparing cancers from the unbiased group of the invited population with controls shows significant differences in distributions for size, grade, and node status but not histological type. Multivariate logistic regression shows significant reduction (odds ratio, 0.73; P = 0.043) in node-positive status for the unbiased group. We conclude that annual mammography from age 40 years significantly reduces size and positive-node status of invasive cancers in the invited population. The potential for phenotypic drift of grade emphasizes the relevance of screen detection of all grades at sizes smaller than 10 mm.
dc.format.extent1252 - 1259
dc.languageeng
dc.language.isoeng
dc.titleInfluence of annual mammography from age 40 on breast cancer pathology
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/j.humpath.2004.07.011
rioxxterms.licenseref.startdate2004
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfHuman Pathology
pubs.noteskeywords: breast cancer, screening, pathology, age, randomized trial
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Cancer Screening Evaluation Unit (DoH)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Cancer Screening Evaluation Unit (DoH)
pubs.volume35
pubs.embargo.termsNot known
icr.researchteamCancer Screening Evaluation Unit (DoH)en_US
dc.contributor.icrauthorMoss, Susan Maryen
dc.contributor.icrauthorWaller, Michaelen


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