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dc.contributor.authorAlvares, CLen_US
dc.contributor.authorMatutes, Een_US
dc.contributor.authorScully, MAen_US
dc.contributor.authorSwansbury, Jen_US
dc.contributor.authorMin, Ten_US
dc.contributor.authorGruszka-Westwood, AMen_US
dc.contributor.authorAtkinson, Sen_US
dc.contributor.authorHilditch, Ben_US
dc.contributor.authorMorilla, Ren_US
dc.contributor.authorWotherspoon, ACen_US
dc.contributor.authorCatovsky, Den_US
dc.identifier.citationLEUKEMIA & LYMPHOMA, 2004, 45 pp. 769 - 775en_US
dc.description.abstractDiffuse large B cell lymphoma (DLBL) comprises a heterogenous entity characterized by the presence of large cells, exhibiting a mature B cell phenotype. The high proliferation rate and aggressive disease remain a therapeutic challenge, but the apparent biological diversity permits a risk-stratification model for prognostic grouping through the International Prognostic Index (IPI). Empirical to this approach is the consideration of cytogenetic data, offering an insight into the pathogenetic events which may underlie neoplastic clonal evolution and disease progression. We describe three cases of DLBL presenting with isolated marrow disease, a rare primary finding in this lymphoma. All three cases showed involvement of blood and bone marrow without evidence of splenic or lymph node involvement on imaging studies. Histological and immunophenotypic findings were similar in all three cases, outlining the phenotypic maturity of this disease. Cytogenetic analysis revealed complex karyotypes in the two cases examined. M-FISH (multicolour fluorescent in situ hybridization) performed on bone marrow from case 1 showed several cryptic translocations not evident on G-banding, including a novel translocation between 2p and 9p, and an unbalanced translocation between 14q and 11q. Cytogenetic analysis in case 2 showed abnormalities involving 7q, 9p at the site of the INK4a gene, and the bcl-2 locus, findings confirmed by M-FISH. These cases serve to highlight the biological and cytogenetic heterogenity of DLBL and emphasize the need for complementary investigations in the characterization of this entity.en_US
dc.format.extent769 - 775en_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.titleIsolated bone marrow involvement in diffuse large B cell lymphoma: A report of three cases with review of morphological, immunophenotypic and cytogenetic findingsen_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfLEUKEMIA & LYMPHOMAen_US
pubs.notesaffiliation: Catovsky, D (Reprint Author), Royal Marsden Hosp, Acad Dept Haematol & Cytogenet, Fulham Rd, London SW3 6JJ, England. Royal Marsden Hosp, Acad Dept Haematol & Cytogenet, London SW3 6JJ, England. keywords: diffuse large B cell lymphoma; bone marrow involvement; complex karyotype keywords-plus: NON-HODGKINS-LYMPHOMA; TRANSLOCATIONS; MALIGNANCIES research-areas: Oncology; Hematology web-of-science-categories: Oncology; Hematology orcid-numbers: Gruszka, Alicja M/0000-0002-5359-0281 number-of-cited-references: 16 times-cited: 19 usage-count-last-180-days: 0 usage-count-since-2013: 0 journal-iso: Leuk. Lymphoma doc-delivery-number: 754QC unique-id: ISI:000187327900021 da: 2018-09-10en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular Haematology (including Cytogenetics Group and Cell Markers)en_US
dc.contributor.icrauthorCatovsky, Danielen_US
dc.contributor.icrauthorMatutes, Estellaen_US
dc.contributor.icrauthorGruszka-Westwood, Alicjaen_US

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