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Overdiagnosis and overtreatment of breast cancer - Overdiagnosis in randomised controlled trials of breast cancer screening

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Date
2005
ICR Author
Moss, Susan Mary
Author
Moss, S
Type
Journal Article
Metadata
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Abstract
Data from randomised controlled trials of mammographic screening can be used to determine the extent of any overdiagnosis, as soon as either a time equivalent to the lead-time has elapsed after the final screen, or the control arm has been offered screening. This paper reviews those randomised trials for which breast cancer incidence data are available. In recent trials in which the control group has not been offered screening, an excess incidence of breast cancer remains after many years of follow-up. In those trials in which the control arm has been offered screening, although there is a possible shift from invasive to in situ disease, there is no evidence of overdiagnosis as a result of incident screens.
URI
https://repository.icr.ac.uk/handle/internal/2612
DOI
https://doi.org/10.1186/bcr1314
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  • Closed Research Teams
Research team
Cancer Screening Evaluation Unit (DoH)
Language
eng
License start date
2005
Citation
BREAST CANCER RESEARCH, 2005, 7 pp. 230 - 234
Publisher
BIOMED CENTRAL LTD

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