Lessons from a case of T-cell large granular lymphocytic leukaemia suggesting that immunomodulatory therapy is more effective than intensive treatment
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Leukemia treatment strives to eradicate the malignant clone. With T-cell large granular lymphocytic (LGL) leukemia, the onus of treatment appears to be modification of the disease rather than eradication of the clone, We describe a case of T-cell LGL leukemia where aggressive, eradicative type therapy proved ineffective. The patient achieved hematological response to low dose oral methotrexate after failing to respond to and/or tolerate eight previous treatments including CAMPATH-1H and peripheral blood stein cell transplantation. We highlight the resistant nature of the LGL clone and discuss the relative met-its of immunomodulatory type therapy in this disease. (C) 2004 Published by Elsevier Ltd.
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Molecular Haematology (including Cytogenetics Group and Cell Markers)
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LEUKEMIA RESEARCH, 2005, 29 pp. 225 - 228