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dc.contributor.authorWells, CA
dc.contributor.authorSloane, JP
dc.contributor.authorColeman, D
dc.contributor.authorMunt, C
dc.contributor.authorAmendoeira, I
dc.contributor.authorApostolikas, N
dc.contributor.authorBellocq, JP
dc.contributor.authorBianchi, S
dc.contributor.authorBoecker, W
dc.contributor.authorBussolati, G
dc.contributor.authorConnolly, CE
dc.contributor.authorDervan, P
dc.contributor.authorDrijkoningen, M
dc.contributor.authorEllis, IO
dc.contributor.authorElston, CW
dc.contributor.authorEusebi, V
dc.contributor.authorFaverly, D
dc.contributor.authorHeikkila, P
dc.contributor.authorHolland, R
dc.contributor.authorJacquemier, J
dc.contributor.authorLacerda, M
dc.contributor.authorMartinez-Penuela, J
dc.contributor.authorDe Miguel, C
dc.contributor.authorPeterse, JL
dc.contributor.authorRank, F
dc.contributor.authorReiner, A
dc.contributor.authorSaksela, E
dc.contributor.authorSigal-Zafrani, B
dc.contributor.authorSylvan, M
dc.contributor.authorBorisch, B
dc.contributor.authorCserni, G
dc.contributor.authorDecker, T
dc.contributor.authorKerner, H
dc.contributor.authorKulka, J
dc.contributor.authorRegitnig, P
dc.contributor.authorSapino, A
dc.contributor.authorTanous, AM
dc.contributor.authorThorstenson, S
dc.contributor.authorZozaya, E
dc.contributor.authorScreen, EWGB
dc.identifier.citationVIRCHOWS ARCHIV, 2004, 445 pp. 119 - 128
dc.description.abstractTo assess the variability of oestrogen receptor (ER) testing using immunocytochemistry, centrally stained and unstained slides from breast cancers were circulated to the members of the European Working Group for Breast Screening Pathology, who were asked to report on both slides. The results showed that there was almost complete concordance among readers (kappa=0.95) in ER-negative tumours on the stained slide and excellent concordance among readers (kappa=0.82) on the slides stained in each individual laboratory. Tumours showing strong positivity were reasonably well assessed (kappa=0.57 and 0.4, respectively), but there was less concordance in tumours with moderate and low levels of ER, especially when these were heterogeneous in their staining. Because of the variation, the Working Group recommends that laboratories performing these stains should take part in a external quality assurance scheme for immunocytochemistry, should include a tumour with low ER levels as a weak positive control and should audit the percentage positive tumours in their laboratory against the accepted norms annually. The Quick score method of receptor assessment may also have too many categories for good concordance, and grouping of these into fewer categories may remove some of the variation among laboratories.
dc.format.extent119 - 128
dc.titleConsistency of staining and reporting of oestrogen receptor immunocytochemistry within the European Union - an inter-laboratory study
dc.typeJournal Article
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfVIRCHOWS ARCHIV
pubs.notesaffiliation: Wells, CA (Reprint Author), St Bartholomews Hosp, Sch Med, Dept Histopathol, London EC1A 6BE, England. St Bartholomews Hosp, Sch Med, Dept Histopathol, London EC1A 6BE, England. Dept Pathol, Liverpool, Merseyside, England. Inst Canc Res, Canc Screening Evaluat Unit, Sutton, Surrey, England. Univ Porto, Inst Patol & Imunol Mol, Dept Pathol, Oporto, Portugal. St Savvas Hosp, Dept Pathol, Athens, Greece. Hop Hautepierre, Serv Anat Pathol, Strasbourg, France. Univ Florence, Dept Human Pathol & Oncol, I-50121 Florence, Italy. Univ Munster, Gerhard Domagk Inst Pathol, D-4400 Munster, Germany. Ist Anat & Istol Patol, Turin, Italy. Univ Coll Hosp Galway, Inst Clin Sci, Dept Pathol, Galway, Ireland. Mater Hosp, Univ Coll, Dept Pathol, Dublin, Ireland. Univ Hosp, Louvain, Belgium. City Hosp Nottingham, Dept Histopathol, Nottingham, England. Univ Bologna, Osped Bellaria, Sez Anat Patol M Malpigni, Bologna, Italy. CMP Lab, Brussels, Belgium. Univ Helsinki, Haartman Inst, Helsinki, Finland. Acad Ziekenhuis Nijmegen, Natl Expert & Training Ctr Breast Canc Screening, Nijmegen, Netherlands. Inst J Paoli I Calmettes, F-13009 Marseille, France. Ctr Reg Oncol Coimbra, Lab Histopatol, Coimbra, Portugal. Hosp Navarra, Dept Pathol, Pamplona, Spain. Hosp Virgen Camino, Dept Pathol, Pamplona, Spain. Netherlands Canc Inst, Dept Pathol, NL-1066 CX Amsterdam, Netherlands. Univ Copenhagen Hosp, Rigshosp, Dept Pathol, Ctr Lab Med & Pathol, Copenhagen, Denmark. Donauspital, Inst Pathol, Vienna, Austria. Inst Curie, Sect Med & Hosp, Paris, France. Huddinge Univ Hosp, Dept Clin Pathol & Cytol, Stockholm, Sweden. Ctr Med Univ Geneva, Geneva, Switzerland. Bacs Kiskun Cty Teaching Hosp, Dept Pathol, Kecskemet, Hungary. HELIOS Med Ctr, Breast Unit, Dept Pathol, Berlin, Germany. Rambam Med Ctr, Dept Pathol, Haifa, Israel. Semmelweis Univ, Inst Pathol 2, Budapest, Hungary. Karl Franzens Univ Graz, Inst Pathol, Graz, Austria. Lab Natl Sante, Div Anat Pathol, Luxembourg, Luxembourg. Kalmar Cty Hosp, Kalmar, Sweden. keywords: oestrogen receptor; immunohistochemistry; quality assessment; variability keywords-plus: LIGAND-BINDING ASSAY; BREAST-CANCER; PROGESTERONE-RECEPTORS; IMMUNOHISTOCHEMICAL-DEMONSTRATION; PREDICTING RESPONSE; QUALITY-ASSURANCE; HORMONE RECEPTORS; SENSITIVITY; CARCINOMA; TAMOXIFEN research-areas: Pathology web-of-science-categories: Pathology author-email: [email protected] researcherid-numbers: Sapino, Anna/J-4113-2018 orcid-numbers: Sapino, Anna/0000-0003-3542-9571 Ellis, Ian/0000-0001-5292-8474 Regitnig, Peter/0000-0002-1371-1595 number-of-cited-references: 17 times-cited: 31 usage-count-last-180-days: 0 usage-count-since-2013: 1 journal-iso: Virchows Arch. doc-delivery-number: 845TL unique-id: ISI:000223267100003 da: 2018-09-10
pubs.notesNot known
pubs.embargo.termsNot known
dc.contributor.icrauthorColeman, Derecken

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