dc.contributor.author | Beland, FA | |
dc.contributor.author | Churchwell, MI | |
dc.contributor.author | Hewer, A | |
dc.contributor.author | Phillips, DH | |
dc.contributor.author | da Costa, GG | |
dc.contributor.author | Marques, MM | |
dc.date.accessioned | 2018-09-11T10:20:14Z | |
dc.date.issued | 2004-07-23 | |
dc.identifier | 2 | |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 320 pp. 297 - 302 | |
dc.identifier.issn | 0006-291X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2627 | |
dc.identifier.doi | 10.1016/j.bbrc.2004.05.168 | |
dc.description.abstract | The nonsteroidal antiestrogen tamoxifen increases the risk of endometrial cancer; however, the mechanism for the induction of these tumors is not known. Recently, Sharma et a]. [Biochem. Biophys. Res. Commun. 307 (2003) 157], using high performance liquid chromatography (HPLC) with online postcolumn photochemical activation and fluorescence detection, reported the presence of (E)-alpha-(deoxyguanosin-N-2-yl)tamoxifen in DNA from human endometrial explants incubated with tamoxifen. Inasmuch as the methodology used by these investigators does not allow unambiguous characterization of tamoxifen-DNA adducts, we have used two additional techniques (HPLC coupled with electrospray ionization tandem mass spectrometry and P-32-postlabeling analyses) to assay for the presence of tamoxifen-DNA adducts in the human endometrial explant DNA. Tamoxifen-DNA adducts were not detected by either method. (C) 2004 Elsevier Inc. All rights reserved. | |
dc.format.extent | 297 - 302 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | |
dc.title | Analysis of tamoxifen-DNA adducts in endometrial explants by MS and P-32-postlabeling | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1016/j.bbrc.2004.05.168 | |
rioxxterms.licenseref.startdate | 2004-07-23 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | |
pubs.notes | affiliation: Beland, FA (Reprint Author), Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA. Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA. Inst Canc Res, Sutton SM2 5NG, Surrey, England. Univ Tecn Lisboa, Ctr Quim Estrutural, Inst Super Tecn, P-104900 Lisbon, Portugal. keywords: tamoxifen; P-32-postlabeling; HPLC; electrospray ionization tandem mass spectrometry; DNA adducts; endometrial cancer keywords-plus: BREAST-CANCER PREVENTION; TRIALS; WOMEN; GENOTOXICITY; CULTURE research-areas: Biochemistry & Molecular Biology; Biophysics web-of-science-categories: Biochemistry & Molecular Biology; Biophysics author-email: [email protected] researcherid-numbers: Marques, M. Matilde/E-2535-2012 orcid-numbers: Marques, M. Matilde/0000-0002-7526-4962 Phillips, David/0000-0001-8509-3485 Beland, Frederick/0000-0002-2113-6260 number-of-cited-references: 24 times-cited: 15 usage-count-last-180-days: 0 usage-count-since-2013: 2 journal-iso: Biochem. Biophys. Res. Commun. doc-delivery-number: 836PJ unique-id: ISI:000222567700003 da: 2018-09-10 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Human Biomonitoring & Carcinogen Activation | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Human Biomonitoring & Carcinogen Activation | |
pubs.volume | 320 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Human Biomonitoring & Carcinogen Activation | en_US |
dc.contributor.icrauthor | Phillips, David Hunter | en |