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Epithelial stem cells in human prostate growth and disease

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Publication Date
2004-09
ICR Author
Hudson, David
Author
Hudson, DL
Type
Journal Article
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Abstract
Benign prostatic hyperplasia and prostate cancer arise as a consequence of changes in the balance between cell division and differentiation. Little, however, is known about the control of this process. Stem cells are a small population of cells that divide occasionally to produce transit-amplifying cells that in turn produce the differentiated cell types of the tissue. It is believed that cancer cell proliferation is also driven by stem cells. We have shown that around one in 200 prostate epithelial cells have characteristics of stem cells and that these cells are contained within a population with a distinct keratin expression pattern. Work is now ongoing to identify markers for these cells that will allow us to study the role they play in prostatic disease.
URL
https://repository.icr.ac.uk/handle/internal/2631
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Version of record
10.1038/sj.pcan.4500745
Language
English
License start date
2004-09
Citation
PROSTATE CANCER AND PROSTATIC DISEASES, 2004, 7 pp. 188 - 194
Publisher
NATURE PUBLISHING GROUP

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