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dc.contributor.authorHudson, DLen_US
dc.date.accessioned2018-09-11T10:23:04Z
dc.date.issued2004-09en_US
dc.identifier3en_US
dc.identifier.citationPROSTATE CANCER AND PROSTATIC DISEASES, 2004, 7 pp. 188 - 194en_US
dc.identifier.issn1365-7852en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2631
dc.identifier.doi10.1038/sj.pcan.4500745en_US
dc.description.abstractBenign prostatic hyperplasia and prostate cancer arise as a consequence of changes in the balance between cell division and differentiation. Little, however, is known about the control of this process. Stem cells are a small population of cells that divide occasionally to produce transit-amplifying cells that in turn produce the differentiated cell types of the tissue. It is believed that cancer cell proliferation is also driven by stem cells. We have shown that around one in 200 prostate epithelial cells have characteristics of stem cells and that these cells are contained within a population with a distinct keratin expression pattern. Work is now ongoing to identify markers for these cells that will allow us to study the role they play in prostatic disease.en_US
dc.format.extent188 - 194en_US
dc.languageEnglishen_US
dc.language.isoEnglishen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.titleEpithelial stem cells in human prostate growth and diseaseen_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1038/sj.pcan.4500745en_US
rioxxterms.licenseref.startdate2004-09en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfPROSTATE CANCER AND PROSTATIC DISEASESen_US
pubs.notesaffiliation: Hudson, DL (Reprint Author), Inst Canc Res, Male Urol Canc Res Ctr, Bob Champ Prostate Stem Cell Lab, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England. Inst Canc Res, Male Urol Canc Res Ctr, Bob Champ Prostate Stem Cell Lab, Sutton SM2 5NG, Surrey, England. keywords: stem cells; epithelium; differentiation; prostate keywords-plus: LABEL-RETAINING CELLS; IN-VIVO; BONE-MARROW; TERMINAL DIFFERENTIATION; PROTEIN EXPRESSION; KERATIN EXPRESSION; REGIONAL VARIATION; DUCTAL SYSTEM; LUMINAL CELLS; P53 HOMOLOG research-areas: Oncology; Urology & Nephrology web-of-science-categories: Oncology; Urology & Nephrology author-email: david.hudson@icr.ac.uk number-of-cited-references: 77 times-cited: 61 usage-count-last-180-days: 0 usage-count-since-2013: 1 journal-iso: Prostate Cancer Prostatic Dis. doc-delivery-number: 857NK unique-id: ISI:000224124000004 oa: gold_or_bronze da: 2018-09-10en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume7en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorHudson, Daviden_US


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