Publications Repository

Publications Repository

View item 
  •   Home
  • ICR Divisions
  • Other ICR Research
  • View item
  • Home
  • ICR Divisions
  • Other ICR Research
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor

Thumbnail
Date
2004-03-25
ICR Author
Kelland, Lloyd
Author
Pors, K
Paniwnyk, Z
Ruparelia, KC
Teesdale-Spittle, PH
Hartley, JA
Kelland, LR
Patterson, LH
Show allShow less
Type
Journal Article
Metadata
Show full item record
Abstract
Novel 1- and 1,4-substituted chloroethylaminoanthraquinones with DNA binding and alkylating properties along with their respective hydroxyethylaminoanthraquinone intermediates were synthesized. Selected chloroethylaminoanthraquinones were shown to cross-link DNA and alkylate guanines (at low nM concentration) with a preference for reaction sites containing 5’-PyG. A compound (Alchemix) with the bis-chloroethyl functionality confined to one side chain alkylated but did not cross-link DNA. All the 1,4-disubstituted chloroethylaminoanthraquinones were potently cytotoxic (nM IC(50)s) against cisplatin-resistant ovarian cancer cell lines.
URI
https://repository.icr.ac.uk/handle/internal/2646
DOI
https://doi.org/10.1021/jm031070u
Collections
  • Other ICR Research
Language
eng
License start date
2004-03-25
Citation
JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 pp. 1856 - 1859
Publisher
AMER CHEMICAL SOC

Browse

All of ICR repositoryICR DivisionsBy issue dateAuthorsTitlesPublication TypesThis collectionBy issue dateAuthorsTitlesPublication Types
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.