Publications Repository

Publications Repository

View item 
  •   Home
  • ICR Divisions
  • Other ICR Research
  • View item
  • Home
  • ICR Divisions
  • Other ICR Research
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Hypoxia-inducible factor-1 and oncogenic signalling

Thumbnail
Date
2004-03
ICR Author
Ashcroft, Margaret
Author
Bardos, JI
Athcroft, M
Type
Journal Article
Metadata
Show full item record
Abstract
An understanding of underlying mechanisms Involved in the activation of HIF-1 in response to both hypoxic stress and oncogenic signals has important implications for how these processes may become deregulated in human dancer. Changes in microenvironmental stimuli such as hypoxia and growth factors in combination With genetic lesions such as loss or inactivation of p53, PTEN or pVHL or oncogenic activation, can all lead to increased HIF-1 activity This provides cancer cells With a distinct ad Vantage for survival and proliferation, resulting in their ability to form vascular tumours, which are aggressive and metastatic. Accordingly, upregulation of HIF-1alpha, a key component of HIF-1, correlates with a poor treatment outcome Using conventional therapies. A Variety of mechanisms exist that regulate expression of HIF-lalpha. In recent years, it has become clear that an extensive network of signalling cascades converge on HIF-1alpha to regulate the transcriptional response. A better understanding of this regulation may provide 6 basis for the development of new cancer therapies. BioEssays 26:M 269, 2004. (C) 2004 Wiley Periodicals, Inc.
URI
https://repository.icr.ac.uk/handle/internal/2647
DOI
https://doi.org/10.1002/bies.20002
Collections
  • Other ICR Research
Language
eng
License start date
2004-03
Citation
BIOESSAYS, 2004, 26 pp. 262 - 269
Publisher
JOHN WILEY & SONS LTD

Browse

All of ICR repositoryICR DivisionsBy issue dateAuthorsTitlesPublication TypesThis collectionBy issue dateAuthorsTitlesPublication Types
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.