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dc.contributor.authorHudson, DLen_US
dc.identifier.citationCYTOTECHNOLOGY, 2003, 41 pp. 189 - 196en_US
dc.description.abstractThe prostate gland is the site of the second most common cancer in men in the UK, with 9,280 deaths recorded in 2000. Another common disease of the prostate is benign prostatic hyperplasia and both conditions are believed to arise as a result of changes in the balance between cell proliferation and differentiation. There are three types of prostatic epithelial cell, proliferative basal, secretory luminal, and neuroendocrine. All three are believed to be derived from a common stem cell through differentiation along different pathways but the mechanisms behind these processes is poorly understood. In particular, there has until recently been very little information about prostate stem cell growth and differentiation. This review will discuss ways of distinguishing these prostate cell types using markers, such as keratins. Methods available for the culture of prostate epithelial cells and for the characterisation of stem cells both in monolayer and three-dimensional models are examined.en_US
dc.format.extent189 - 196en_US
dc.titleProstate epithelial stem cell cultureen_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
pubs.notesaffiliation: Hudson, DL (Reprint Author), Inst Canc Res, Prostate Stem Cell Lab, 15 Cotdswold Rd, Sutton SM2 5NG, Surrey, England. Inst Canc Res, Prostate Stem Cell Lab, Sutton SM2 5NG, Surrey, England. keywords: benign prostatic hyperplasia; cancer; differentiation; epithelium; keratins; proliferation; proliferative heterogeneity; prostate; stem cells keywords-plus: BASAL CELLS; KERATIN EXPRESSION; IN-VITRO; NEUROENDOCRINE DIFFERENTIATION; CANCER; IDENTIFICATION; GROWTH; CYTOKERATINS; CARCINOMA; PATHWAYS research-areas: Biotechnology & Applied Microbiology; Cell Biology web-of-science-categories: Biotechnology & Applied Microbiology; Cell Biology number-of-cited-references: 39 times-cited: 6 usage-count-last-180-days: 0 usage-count-since-2013: 0 journal-iso: Cytotechnology doc-delivery-number: 703LD unique-id: ISI:000184280100015 oa: green_published da: 2018-09-13en_US
pubs.notesNot knownen_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorHudson, Daviden_US

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