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Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT

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Date
2002-10-02
ICR Author
Willison, Keith
Author
Valpuesta, JM
Martin-Benito, J
Gomez-Puertas, P
Carrascosa, JL
Willison, KR
Type
Journal Article
Metadata
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Abstract
Chaperonins are large oligomers made up of two superimposed rings, each enclosing a cavity used for the folding of other proteins. Among the chaperonins, the eukaryotic cytosolic chaperonin CCT is the most complex, not only with regard to its subunit composition but also with respect to its function, still not well understood. Unlike the more well studied eubacterial chaperonin GroEL, which binds any protein that presents stretches of hydrophobic residues, CCT recognises in its substrates specific binding determinants and interacts with them through particular combinations of CCT subunits. Folding then occurs after the conformational changes induced in the chaperonin upon nucleotide binding have occurred, throng a mechanism that, although still poorly defined, clearly differs from the one established for GroEL. Although CCT seems to be mainly involved in the folding of actin and tubulin, other substrates involved in various cellular roles are beginning to be characterised, including many WD40-repeat, 7-blade propeller proteins. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
URI
https://repository.icr.ac.uk/handle/internal/2707
DOI
https://doi.org/10.1016/S0014-5793(02)03180-0
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Research team
Chromatin Regulation
Language
eng
License start date
2002-10-02
Citation
FEBS LETTERS, 2002, 529 pp. 11 - 16
Publisher
ELSEVIER SCIENCE BV

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