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dc.contributor.authorMeiser, B
dc.contributor.authorButow, P
dc.contributor.authorFriedlander, M
dc.contributor.authorBarratt, A
dc.contributor.authorSchnieden, V
dc.contributor.authorWatson, M
dc.contributor.authorBrown, J
dc.contributor.authorTucker, K
dc.date.accessioned2018-09-17T15:11:05Z
dc.date.issued2002
dc.identifier15
dc.identifier.citationEuropean Journal of Cancer, 2002, 38 pp. 2025 - 2031
dc.identifier.issn0959-8049
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2708
dc.identifier.doi10.1016/S0959-8049(02)00264-2
dc.description.abstractPsychological adjustment in 90 women (30 carriers and 60 non-carriers) who had undergone genetic testing for mutations in BRCA1 and BRCA2 breast/ovarian cancer susceptibility genes was compared with that of 53 women who were not offered genetic testing. Women were assessed prior to genetic testing and 7–10 days, 4 and 12 months after carrier status disclosure using self-administered questionnaires. Compared with women not offered testing, mutation carriers had significantly higher breast cancer distress 7–10 days (t=2.80, P=0.005) and 12 months (t=2.01, P=0.045) post-notification. Non-carriers showed a significant decrease in state anxiety 7–10 days post-notification (t=2.27, P=0.024) and in depression 4 months post-notification (t=2.26, P=0.024), compared with women not offered testing. These data show that non-carriers derive psychological benefits from genetic testing. Women testing positive may anticipate a sustained increase in breast cancer distress following disclosure, although no other adverse psychological outcomes were observed in this group.
dc.format.extent2025 - 2031
dc.languageeng
dc.language.isoeng
dc.titlePsychological impact of genetic testing in women from high-risk breast cancer families
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/S0959-8049(02)00264-2
rioxxterms.licenseref.startdate2002
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfEuropean Journal of Cancer
pubs.noteskeywords: Psychological impact, Genetic counselling, Hereditary breast cancer
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Psychology Research Group
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Psychology Research Group
pubs.volume38
pubs.embargo.termsNot known
icr.researchteamPsychology Research Groupen_US
dc.contributor.icrauthorWatson, Maggieen


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