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dc.contributor.authorRolink, AG
dc.contributor.authorSchaniel, C
dc.contributor.authorBruno, L
dc.contributor.authorMelchers, F
dc.date.accessioned2018-09-17T15:11:19Z
dc.date.issued2002
dc.identifier1
dc.identifier.citationImmunology Letters, 2002, 82 pp. 35 - 40
dc.identifier.issn0165-2478
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2710
dc.identifier.doi10.1016/S0165-2478(02)00016-0
dc.description.abstractIn mice deficient for the transcription factor Pax-5, B cell development is blocked at the pre-B I cell stage. Like wild type, Pax-5−/− pre-B I cells can be grown long-term in vitro in the presence of stromal cells and IL-7. However, unlike their wild type in vitro grown counterparts, Pax-5−/− pre-B I cells posses an extraordinary developmental plasticity showing hematopoeitic stem cell features such as multipotency and self renewing capacity. Here we review and discuss this in vitro and in vivo plasticity of Pax-5−/− pre-B I cells.
dc.format.extent35 - 40
dc.languageeng
dc.language.isoeng
dc.titleIn vitro and in vivo plasticity of Pax5-deficient pre-B I cells
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/S0165-2478(02)00016-0
rioxxterms.licenseref.startdate2002
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfImmunology Letters
pubs.noteskeywords: Mice, Pax-5, Cells
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.volume82en_US
pubs.embargo.termsNot known
dc.contributor.icrauthorLudovica, Brunoen


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