An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines
Date
2002-11ICR Author
Author
Vlachou, M
Tsotinis, A
Kelland, LR
Thurston, DE
Type
Journal Article
Metadata
Show full item recordAbstract
A number of pyrroloisoquinolines have been prepared by reaction of 5-nitroisoquinoline with vinylmagnesium bromide followed by N-alkylation with the appropriate 2-chloro-N,N-dialkylethylamine. Their cytotoxicity was evaluated in a number of ovarian cell lines and compared to their analogous isomeric pyrroloquinolines. Two of the new compounds, 7c and 7d, are selective toward the A2780 cisplatin-resistant line. (C) 2002 Elsevier Science B.V. All rights reserved.
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Language
eng
License start date
2002-11
Citation
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 17 pp. 139 - 143
Publisher
ELSEVIER SCIENCE BV