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An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines

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Date
2002-11
ICR Author
Kelland, Lloyd
Author
Vlachou, M
Tsotinis, A
Kelland, LR
Thurston, DE
Type
Journal Article
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Abstract
A number of pyrroloisoquinolines have been prepared by reaction of 5-nitroisoquinoline with vinylmagnesium bromide followed by N-alkylation with the appropriate 2-chloro-N,N-dialkylethylamine. Their cytotoxicity was evaluated in a number of ovarian cell lines and compared to their analogous isomeric pyrroloquinolines. Two of the new compounds, 7c and 7d, are selective toward the A2780 cisplatin-resistant line. (C) 2002 Elsevier Science B.V. All rights reserved.
URI
https://repository.icr.ac.uk/handle/internal/2718
DOI
https://doi.org/10.1016/S0928-0987(02)00163-X
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  • Other ICR Research
Language
eng
License start date
2002-11
Citation
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 17 pp. 139 - 143
Publisher
ELSEVIER SCIENCE BV

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